adoptive transfer


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Related to adoptive transfer: Flow cytometry, transgenic

Adoptive Immunotherapy

A form of passive immunisation in which sensitised cells or serum are transferred to an immunologically naive or lymphocyte-depleted recipient—e.g., for managing cancer, as in the use of IL-2/LAK cells.
About 10% of patients with terminal renal cell carcinoma and melanoma achieve partial or complete remission with LAK/IL-2; some response to LAK cells may occur in colorectal carcinoma and Hodgkin lymphoma; the effects may be dose-dependent, non-MHC-restricted, and require simultaneous high-dose IL-2.

adoptive transfer

the transfer of cells, commonly lymphocytes from an immunized individual, to a non-immune recipient.
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For both adoptive transfer systems, at 36 hr posttransfer, cells from blood, peripheral lymph nodes, and spleen were harvested from a subset of recipients, and the remainder of recipients were infected with IAV.
Induction of Tolerance by Adoptive Transfer of Treg Cells.
In the adoptive transfer technique, investigators used a small fragment of a patient's melanoma to grow the patient's own T cells in vitro (Science, 19 September 2002 [10.
Yee's research has been focused on the isolation of autologous antigen-specific T cells from the peripheral blood, manipulation of immune modulating parameters to enhance effector function and persistence, and their expansion to numbers sufficient for adoptive transfer and in vivo tracking.
Adoptive transfer of M2 macrophages into fungal sensitized and challenged mice resulted in exacerbated inflammation and fibrosis in the lung, whereas adoptive transfer of naove macrophages reduced inflammation and fibrosis.
Adoptive Transfer of ZFN Mediated CCR5 Modified CD4 T-cells (SB-728-T) in HIV Subjects Leads to Long Term Engraftment of HIV Resistant T Memory Stem Cells and Decrease in Size of Latent Reservoir -- Abstract #C-7 Session: Clinical Trials Spotlight Oral Presentation -- Thursday, May 14, 2015
H2-794a: "HAART Treatment Interruption following Adoptive Transfer of Zinc Finger Nuclease (ZFN) Modified Autologous CD4+ T-cells (SB-728-T) to HIV-infected Subjects Demonstrates Durable Engraftment and Suppression of Viral Load" Presenters: Dale Ando, M.
In the study, recipient athymic mice were irradiated sublethally and injected with human hepatoma cells followed by the adoptive transfer of splenocytes from donor mice.
H2-794a: "HAART Treatment Interruption following Adoptive Transfer of Zinc Finger Nuclease (ZFN) Modified Autologous CD4 T-cells (SB-728-T) to HIV-infected Subjects Demonstrates Durable Engraftment and Suppression of Viral Load"
Adoptive transfer of CD11c+ DCs from tolerant CD83-treated animals induced kidney allograft tolerance in syngeneic recipients.
Recipients were challenged with a tumorigenic dose of 4T1 cells 3 days after adoptive transfer and primary and secondary tumor growth in the recipients was examined.