adjuvant vaccine

ad·ju·vant vac·cine

a vaccine that contains an adjuvant; the antigen (immunogen) is included in a water-in-oil emulsion (Freund incomplete type adjuvant), or is adsorbed onto an inorganic gel (alum, aluminum hydroxide or phosphate) or mixed with another material to prevent rapid elimination by the host.
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Based on the Phase II results, a high-dose plus adjuvant vaccine formulation administered on days 0, 7 and 30 was selected for further evaluation in the global efficacy program, Cdiffense .
Composite ELISA ranking analysis determined that the high-dose plus adjuvant vaccine formulation (Group 3) generated the greatest immune response over a 60-day period.
Similarly, at ASCO 2008, investigators in the phase III EORTC (European Organisation for Research and Treatment of Cancer) 18961 trial reported that an adjuvant vaccine that was targeted against a ganglioside that was overexpressed on most melanoma cells did not improve distant metastasis-free survival, and that an early interim analysis suggested a detriment to overall survival.
Further evidence for the capacity of previous N2 experience to moderate the challenge of the Hong Kong virus was provided by Eickhoff and Meiklejohn (20), who showed that vaccination of Air Force cadets with an H2N2 adjuvant vaccine reduced subsequent influenza from verified H3N2 virus infection by 54%.
Eickhoff TC, Meiklejohn G Protection against Hong Kong influenza by adjuvant vaccine containing A2-Ann Arbor-67, Bull World Health Organ.
A Phase II trial of the adjuvant vaccine, aimed at the lethal H5NI bird flu virus, is to begin by the end of 2009.
Again, experience of adjuvant vaccines in pregnancy suggests there are no safety concerns.
The commercial & business development of novel adjuvant vaccines
Additionally, the Company, together with its local partners, plans to develop adjuvant vaccines to treat influenza, such as H5N1 and H1N1 strains.