adjuvant analgesics

adjuvant analgesics

range of membrane-stabilizing drugs used to enhance analgesia and increase pain tolerance when conventional analgesics (paracetamol, codeine, tramadol, morphine) are non-effective; antidepressants (e.g. amitriptyline), anticonvulsants (e.g. gabapentin, carbamazepine), antiarrhythmics (e.g. lidocaine, mexiletine), N -methyl-d-aspartic acid (NMDA) antagonists (e.g. ketamine), centrally acting antihypertensives (e.g. clonidine)
References in periodicals archive ?
morphine, codeine, and pethidine), and adjuvant analgesics (e.
Adjuvant analgesics are medications whose primary indication is something other than pain, but act as an analgesic for some conditions.
Adjuvant analgesics include antidepressants and antiepileptic drugs used for the treatment of neuropathic pain.
These adjuvant analgesics combat central sensitization, a condition that occurs when the central nervous system remains in a persistent state of pain reactivity even after an initial injury is healed.
The physiological evidence supports the inclusion of medication previously considered as coanalgesics or adjuvant analgesics as primary analgesics.
Dr Kuritzky reviews the adjuvant analgesics commonly used, focusing on how to initiate therapy based on patient characteristics, as well as to modify therapy based on patient response.
Mild to moderate cases also may require adjuvant analgesics, anticonvulsants, and antidepressants.
Choosing among the adjuvant analgesics can be challenging.
In addition to duloxetine and pregabalin, which have been approved by the FDA for DPNP, adjuvant analgesics are the mainstay of therapy.
15,16) Consequently, the management of neuropathic pain relies on the skillful use of adjuvant analgesics and the judicious use of long-term opioid therapy.
21-24) The studies investigating adjuvant analgesics in neuropathic pain are generally placebo-controlled with no comparison to other adjuvant analgesic therapy.
Adjuvant analgesics, eg, antidepressants, anticonvulsants, topical agents, and opioids are the mainstay of treatment for chronic neuropathic pain (C).