adiponectin


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Related to adiponectin: ghrelin, Resistin

ad·i·po·nec·tin

(ad'i-pō-nek'tin),
Protein hormone produced and secreted by adipocytes into the systemic blood circulation; causes sensitivity of peripheral tissues to insulin.
[adipo- + L. necto, to fasten, + -in]

adiponectin

(ăd′ə-pə-nĕk′tĭn)
n.
A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

Adiponectin

A circulating protein encoded by ADIPOQ on chromosome 3q27, which is secreted exclusively by mature adipocytes. It is a key adipokine in the control of fat metabolism and insulin sensitivity, and has direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilisation and fatty acid hydrolysis. It antagonises TNF-alpha by down-regulating its expression in the liver, macrophages and elsewhere, and by counteracting its direct effects. It inhibits endothelial NF-kappa-B signalling by a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on complex size—low, medium, or high molecular weight.

ad·i·po·nec·tin

(ad'i-pō-nek'tin)
Protective adipokine that reduces lipid accumulation and endothelial adhesion resulting from vascular injury; increases skeletal muscle oxidation of free fatty acids; reduces hepatic glucose output; increases peripheral insulin sensitivity.
[adipo- + L. necto, to fasten, + -in]

adiponectin

A cytokine derived from adipose tissue that has antidiabetic and antiatherosclerotic properties.
References in periodicals archive ?
Serum levels of visfatin (Cusabio, China), adiponectin (Medignost, Germany), LH (DiaMetra, Germany), FSH (DiaMetra, Germany), and prolactin (DiaMetra, Germany) were measured by ELISA Reader (Statfax2600, USA).
Like the previous STELLUX[R] chemiluminescence assays offered by ALPCO, the STELLUX[R] Adiponectin ELISAs include three control levels, as well as a lot-specific validation package, providing confidence in quality and performance.
For NF-[kappa]B and adiponectin detection, fixed cells were incubated overnight with each antibody, i.
Demonstrating a clear influence on TEF, postprandial NEFA suppression and increased adiponectin levels in obese women through longer duration of meal times, the results from this study could provide some practical and tangible strategies to incorporate into a clinical setting.
Interestingly, cadherin 13, the protein encoded by CDH13 is functionally linked to adiponectin, a predominantly anti-inflammatory adipokine.
Adiponectin, Insulin, and Pro- Insulin: Staging the Progression of Insulin Resistance to Prediabetes and Diabetes Type 2
Adiponectin reportedly plays a key role in the development of insulin resistance and atherosclerosis, the building up of plaque in the arteries which leads to stroke, heart attack or death.
Aliquots of co-culture plasma were incubated in 96-well antibody-coated plates to analyze the proteins with commercially available ELISA kits (IGF-1 and IGFBP-3: DIAsource, Nivelles, Belgium; adiponectin and leptin: Millipore Corp, Billerica, MA).
Takashi Kadowaki, MD, PhD (Professor of Diabetes and Metabolic Diseases, University of Tokyo), has been doing research on adiponectin for over a decade.
Adiponectin (also termed acrp 30, adipoQ, APM-1, GBP28) is an adipocytokine that is generally and abundantly expressed in adipose tissue and directly sensitizes the cells to insulin.
Fat cells (adipocytes) produce adipokines, including leptin, tumor necrosis factor (TNF)-[alpha], interleukin (IL)-6, C reactive protein (CRP), and adiponectin.