Plasma samples were analyzed both undiluted and 100X diluted in serum diluent (R & D Systems) and PBS (1:1), the latter for measurement of plasma adipokines
present in very high concentrations, i.
46) As described in the accompanying article, surplus lipids lead to lipotoxicity and apoptosis, while adipokines
promote inflammation, atherosclerosis, and CVD.
She also was interested in learning about adipokines
that are found in fat cells, and she wanted to "decrease housing for these chemicals" as much as she could.
Postnatal programming of glucocorticoid metabolism in rats modulates high-fat diet-induced regulation of visceral adipose tissue glucocorticoid exposure and sensitivity and adiponectin and proinflammatory adipokines
gene expression in adulthood.
Atrial natriuretic peptide inhibits the production of adipokines
and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue.
Obesity and prostate cancer: a role for adipokines
The sixteen rare young adult obesity-discordant identical (monozygotic) twin pairs (intra-pair difference in BMI aAeAN3kg/m2 and BMI range 20-40 and aged 23-36 years, were examined for detailed characteristics of metabolic health (subcutaneous-, intra-abdominal- and liver fat [magnetic resonance imaging (MRI)/ spectroscopy]), an oral glucose tolerance test (OGTT-to determine how quickly glucose is cleared from the blood), lipids, and certain markers of inflammation such as adipokines
and C-reactive protein (CRP).
Macronutrient composition and increased physical activity modulate plasma adipokines
and appetite hormones during a weight loss intervention.
James Nishimuta and Marc Levenston from the Mechanical Engineering Department at Stanford University in California have been investigating the effects of adipokines
They include a stress reaction by the body and adipooe hypertrophy which leads to increased expansion of pro- and anti-inflammatory mediators called adipokines
, and eventually may progress to cell rupture with a resulting inflammatory response (6).
One possible explanation for this phenomenon is that fat cells may produce adipokines
, which may have a proinflammatory effect.
Elevated levels of free fatty acids, insulin and several adipokines
, as observed in metabolic syndrome, induce hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) gene expression in the liver.