adipocytokine


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Adipokine

A generic term for cytokines and other modulating proteins which are secreted by adipocytes. Some—e.g., IL-6—are pro-inflammatory,  whilst others—e.g., adiponectin—have anti-inflammatory or insulin-sensitising properties. Adipokine dysregulation appears to play a central role in adiposity, metabolic syndrome, and the co-morbidities of obesity including cardiovascular disease.

adipocytokine

, adipokine (ad″ĭ-pō-sīt′ŏ-kīn″) (ad′ĭ-pŏ-kīn″) [ adipo- + cytokine]
A molecule secreted by fat cells that affects the physiology of cells in other parts of the body. Some of these molecules influence appetite, the storage of fat in the body, and systemic inflammation.
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References in periodicals archive ?
Effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in patients with type 2 diabetes mellitus.
In addition, 5/7 PPAR signaling genes (solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6), carnitine palmitoyltransferase 2 (CPT2), SORBS1, phosphoenolpyruvate carboxykinase 1 (PCK1) and SLC27A1) and 4 adipocytokine signaling pathway genes (OB, PRKAG2, PCK1, and PPARGC1A) were upregulated in the H group, which are significant to the development of marbling.
The topics include developmental origins of insulin resistance and type 2 diabetes, endocrine aspects, brain insulin resistance, cardio-respiratory fitness, mental illness, inflammation, adipocytokine dysregulation and obesity, non-alcoholic fatty liver disease, polycystic ovary syndrome, the relevance of nutrition in developing and treating the metabolic syndrome, and treatments.
Leptin, an adipocytokine also expressed endogenously in the brain, decreases A[beta] levels and ameliorates tau phosphorylation in the brain.
Moschen AR, Kaser A, Enrich B et al: Visfatin, an adipocytokine with proinflammatory and immunomodulating properties.
The adipocytokine TNF-[alpha] was previously shown to induce endothelial cell dysfunction and atherogenesis (Zhang et al.
Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer.
2005) Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes.