adherens junction


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adherens junction

a component of the junctional complex just beneath and supporting the zonula occludens. The extracellular space at the adherens junction is spanned by the extracellular aspects of cadherin molecules, the intracellular aspects of which are supported by actin filaments.

Adherens Junction

A protein complex located at the junction between epithelial cells, which are subjected to stretching and pulling, yet require tight contact between them so they can function as a single unit. Adherens junctions are linked to the cell’s actin cytoskeleton, and take two forms: as bands encircling the cell—zonula adherens—or as “spot welds” to the extracellular matrix—adhesion plaques. Adherens junctions are composed of 4 principle proteins: cadherins and alpha-catenin, plakoglobulin (aka beta or gamma catenin) and p120 (aka delta catenin).

adherens junction

A point of junction between cells at which ACTIN filaments from inside the cells pass across the adjacent cell membranes. A broad, belt-like adherens junction is called an adhesion belt.
References in periodicals archive ?
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: A review of recent data," Developmental Biology 286(1): 1-15.
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier integrity: An in vivo study using an androgen suppression model," Journal of Cellular Physiology 205(1): 141-157.
Interactions among IQGAP1, Cdc42, and the cadherin/catenin protein complex regulate Sertoli--germ cell adherens junction dynamics in the testis," Journal of Cellular Physiology 202(1): 49-66.
Regulation of Sertoli--germ cell adherens junction dynamics via changes in protein--protein interactions of the N-cadherin-[beta]-catenin protein complex which are possibly mediated by c-Src and myotubular-in-related protein 2: An in vivo study using an androgen suppression model," Endocrinology 146(3): 1268-1284.
Zyxin, axin, and Wiskott-Aldrich syndrome protein are adaptors that link the cadherin/catenin protein complex to the cytoskeleton at adherens junctions in the seminiferous epithelium of the rat testis," Journal of Andrology 25(2): 200-215.
Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway," Biology of Reproduction 68(6): 2189-2206.
Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis?
Molecular and functional analysis of cadherin-based adherens junctions.
Much of this is performed via three mechanisms existing between the intestinal microvilli: tight junctions, adherens junctions and desmosomes.
One domain consists of the contacts between the sarcolemma and the junctional sarcoplasmic reticulum (cytoskeletal domain), another contains caveolae (caveolae are microdomains of the plasma membrane that have been implicated in signal transduction), and the third contains adherens junctions, which are also referred to as membrane-associated dense bodies.
Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.
NACHYLINE[R]: NACHYLINE[R] stimulates both the formation of adherens junctions and keratinocyte differentiation, reinforcing thus the cohesion and the stratification of the epidermis.