i/o] subtypes activate the enzyme adenylyl
cyclase, which catalyzes the formation of a second messenger called cyclic adenosine monophosphate (cAMP).
The company said the RT-100 AC6 gene transfer involves infusing an inactivated adenovirus vector encoding human adenylyl
cyclase type 6 (Ad5.
P2Y receptors), adenylyl
cyclase, and cyclic adenosine monophosphate synthesis.
1999), cytochrome c oxidase in sponge larvae (Bjorn and Rasmusson, 2009), and photoactivated adenylyl
cyclase in euglenoids (Ntefidou et al.
Activation of D2R could lead to the lower level of intracellular cyclic adenosine monophosphate (cAMP) due to the inhibition of the adenylyl
cyclase enzyme and then resulted in the less expression of clock genes through the cAMP-responsive element (CRE).
Melatonin inhibits pituitary adenylyl
cyclase-activating polypeptide-induced increase of cyclic AMP accumulation and [Ca2+] in cultured cells of neonatal rat pituitary.
Inactivated mutation of the FSH receptor (FSHR) gene damages adenylyl
cyclase stimulation, while the receptor remains captured inside the cell.
The production of prostaglandin endoperoxides from arachadonic acid in the endothelium, specifically PGI2, stimulates adenylyl
cyclase to convert adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), which also facilitates pulmonary vasodilatation.
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl
7,8 Its smooth muscle-relaxing action is brought about through the increase in myometrial cyclic adenosine monophosphate (cAMP) due to the activation of adenylyl
cyclase by the stimulation of b2 receptors, leading to a decrease in uterus contractions.
2006), and forskolin to the direct activation of adenylyl
cyclase at the vascular smooth muscle.
Animal studies suggest that OPs may restrict fetal growth, possibly by influencing the adenylyl
cyclase signaling cascade, by increasing thyroxine levels, or by effects on placental transport of nutrients (Eskenazi et al.