adenylosuccinate lyase


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ad·e·nyl·o·suc·ci·nate ly·ase

(ad'e-nil-ō-sŭk'sin-āt lī'ās), [MIM*103050]
Adenylylsuccinate lyase; an enzyme catalyzing the nonhydrolytic cleavage of adenylosuccinic acid producing AMP and fumarate and also of 4-(N-succinocarboxamido)-5-aminoimidazole nucleotide to yield fumarate and aminoimidazole carboxamide ribosyl-5-phosphate. Both are steps in purine nucleotide biosynthesis.
References in periodicals archive ?
The diversity of adenylosuccinate lyase (Ads1) gene and its relationship with Inosinic acid content in chicken.
Concentration in urine, [micro]mol/mmol creatinine Metabolite NMR HPLC Metabolic defect Allopurinol 630 1007 Molybdenum cofactor Deoxyadenosine 205 185/167 (b) ADA Deoxyguanosine 322 177 PNP Deoxyinosine 522 333 PNP Guanosine 588 490 PNP Hypoxanthine 271 194 Xanthine oxidase 227 171 Xanthine oxidase 22 14/47 (b) Molybdenum cofactor 1022 1048 HGPRT Inosine 1110 523 PNP SAICA-riboside 214 298 Adenylosuccinate lyase 162 126 Adenylosuccinate lyase Succinyladenosine 188 283 Adenylosuccinate lyase 101 157 Adenylosuccinate lyase Thymine 335 54 Dihydropyrimidine dehydrogenase Uracil 626 342 Dihydropyrimidine dehydrogenase Xanthine 229 182 XDH 843 794 XDH 431 286/643 (b) Molybdenum cofactor 358 957 HGPRT (a) HPLC values were not measured simultaneously with the NMR values (see Results).