adenylate cyclase


Also found in: Dictionary, Acronyms, Wikipedia.
Related to adenylate cyclase: cyclic AMP, Phospholipase C, Protein kinase A

adenylate cyclase

 [ah-den´ĭ-lāt si´clās]
an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and inorganic pyrophosphate (PPi ). It is activated by the attachment of a hormone or neurotransmitter to a specific membrane-bound receptor.

a·den·y·late cy·clase

an enzyme acting on ATP to form 3',5'-cyclic AMP plus pyrophosphate, a crucial step in the regulation and formation of second messengers.
Synonym(s): 3', 5'-cyclic AMP synthetase

adenylate cyclase

(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also

adenyl cyclase

(ə-dĕn′əl, ăd′n-ĭl)
n.
An enzyme that catalyzes the formation of cyclic AMP from ATP and plays a key role in signal transduction.

adenylate cyclase

an enzyme that initiates the conversion of adenosine triphosphate to cyclic adenosine monophosphate, a mediator of many physiological activities.

Adenylate Cyclase

An enzyme that catalyses ATP to form 3’,5’-cyclic AMP and inorganic pyrophosphate. G proteins dissociate into GTP-bound alpha subunits—activating adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels—and a complex of beta and gamma subunits, selectively activating certain forms of adenylate cyclase following interaction with the cell receptors. Adenylate cyclase is intimately linked to the receptor-G protein machinery on the cytoplasmic face of cell membrane, which generates the second messenger, cAMP, when stimulated by an extracellular message in the form of receptor binding of a hormone or other ligand, light, or odours. Adenylate cyclase is the prototypic second messenger generator, and is regulated by one or the other arm of the phospholipase C pathway. It is further regulated by cyclic changes in cAMP and internal Ca2+ levels.

a·den·y·late cy·clase

(ă-den'i-lāt sī'klās)
An enzyme acting on ATP to form 3',5'-cyclic AMP plus pyrophosphate. A crucial step in the regulation and formation of second messengers.
Synonym(s): 3', 5'-cyclic AMP synthetase.

adenylate cyclase

The enzyme that converts ADENOSINE TRIPHOSPHATE (ATP) to cyclic AMP.

adenylate

a salt, anion or ester of adenylic acid.

adenylate cyclase
an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP) and inorganic pyrophosphate. It is activated by the attachment of a hormone or neurotransmitter to a specific membrane-bound receptor.
adenylate kinase
enzyme catalyzing the conversion of two moles of ADP to ATP and AMP, thereby equilibrating ADP with ATP and AMP. Controls the adenylate energy charge of a cell, particularly muscle cells. Called also myokinase.
References in periodicals archive ?
The inhibitory effect of daidzein was still observed when lipolysis was induced by direct activation of adenylate cyclase (by forskolin) or PKA (by dibutyryl-cAMP) (Fig.
Effects of sub-chronic in vivo chlorpyrifos exposure on muscarinic receptors and adenylate cyclase of rat striatum.
This mutant lacks adenylate cyclase activity, but it does have a CAP phenotype; in the absence of cAMP it is able to express genes that normally require cAMP.
Transgenic and Knockout Mouse Models Used in Alcohol Research Candidate Gene/Protein Phenotype Transgenic models Acetaldehyde (ADH) Exacerbation of alcoholic heart muscle disease in transgenic hearts Adenylate cyclase 7 (AC7) Reduced initial sensitivity to alcohol- induced ataxia and sedation in transgenic mice Bcl-2 (cell death) Overexpression of bcl-2 protects repressor gene cerebellar neurons from alcohol neurotoxicity Gama-aminobutyric [acid.
The activity of the other enzyme, adenylate cyclase, was substantially lower among the alcoholics than among the nonalcoholics after blood samples were exposed to cesium fluoride, a substance that stimulates this enzyme.
Vasoactive intestinal peptide receptor 1 (VPAC1) couples heterotrimeric G proteins, Gas and G[alpha]i, that activate and inhibit adenylate cyclase cAMP production.
bronchiseptica, it does not carry genes that encode pertussis toxin or adenylate cyclase toxin (7).
Although both FSH and LH act through stimulatory G protein-coupled receptors (GCPRs), activation of adenylate cyclase and production of the second-messenger cyclic adenosine monophosphate (cAMP, Jonassen et al.
Lithium acts by altering intraneuronal metabolism of catecholamines, inhibiting noradrenaline-sensitive adenylate cyclase, reducing synaptic transmission, and increasing neuronal excitability with modification of the central nervous system (CNS) amine concentrations.
This new research effort provides further scientific support for the potential therapeutic use of an adenylate cyclase gene (AC-6) to boost the production of an enzyme in the myocardial adrenergic signaling pathway to improve heart function.