Forskolin, one of these diterpenes, directly acts on adenyl
cyclase and leads to increased intracellular levels of the second messenger cAMP.
2+] channel blockade results in modulation in the adenyl
cyclase effectors system activated by [mu],-opioid receptor activation, leading to the suppression of opioid tolerance and restoration of super-sensitivity (Hurle et al.
The pathogenesis of FD involves somatic activating mutation of the gene encoding the alpha subunit of the stimulatory G protein in the bone marrow cells, resulting in locally increased stimulatory activity of adenyl
cyclase and cAMP.
Bromocriptine is an ergot alkaloid derivative, structurally related to dopamine (1) Bromocriptine is a dopamine receptor agonist that inhibits prolactin secretion (2, 3, 4, 5) through the inhibition of adenyl
cyclase activity (1) and is commonly used in the treatment of hyperprolactinemia, Parkinsonism and acromegaly (6,7).
Clopidogrel may block ADP-induced platelet aggregation via G protein activation and inhibition of adenyl
cyclase or it may be totally independent from these factors.
In vitro studies show that opioids inhibit activation of adenyl
cyclase (6) and also stimulate the formation of cGMP (7).
The pharmacologic effects of a beta 2-adrenoceptor agonist drugs stimulate adenyl
cyclase to cyclic 3'5' adenosine monophosphate (cyclic AMP).
Cholera--The cholera enterotoxin produced by Vibrio cholerae stimulates adenyl
cyclase, an intestinal enzyme that causes secretion of large volumes of watery fluid (as much as one L/hour).
Numerous enzymes, such as adenyl
cyclase and protein kinase A involved in energy regulation, are upregulated by DHA.
Somatostatin receptors, an expanding gene family: cloning and functional characterisation of human SSTR3, a protein coupled to adenyl
Epinephrine, a primary messenger acts by activating the adenyl
cyclase system which catalyzes the synthesis of cyclic AMP from ATP.
Epinephrine activates the enzyme adenyl
cyclase, which subsequently activates the phosphorylase enzyme system which, ultimately, converts glucose to glucose-6-phosphate (G6P).