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adenomatous polyposis coli

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
adenomatous polyposis coli (APC),
a gene associated with familial adenomatous polyposis (FAP), an inherited disorder characterized by the development of myriad polyps in the colon, often occurring in adolescents and young adults ages 15 to 25. Untreated, the condition nearly always leads to colon cancer. The gene is located on chromosome 5.

adenomatous polyposis coli
Familial adenomatous polyposis, see there. See APC gene, APC protein.


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Mutations in the Adenomatous Polyposis Coli (APC) gene are the critical initiating step in most cases of FAP and sporadic cancers.
Using Indivumed's highly standardized biobank, the researchers found elevated levels of mutated adenomatous polyposis coli (APC) gene in the plasma of patients with advanced stage colorectal cancers.
4) It is proposed that the adenomatous polyposis coli (APC) gene is lost or mutated early in this process in normal epithelium, leading to hyperproliferative epithehum in the intestine.
 
 
 
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