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adenomatous polyposis coli |
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adenomatous polyposis coli (APC), a gene associated with familial adenomatous polyposis (FAP), an inherited disorder characterized by the development of myriad polyps in the colon, often occurring in adolescents and young adults ages 15 to 25. Untreated, the condition nearly always leads to colon cancer. The gene is located on chromosome 5. adenomatous polyposis coli Familial adenomatous polyposis, see there. See APC gene, APC protein. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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Using Indivumed's highly standardized biobank, the researchers
found elevated levels of mutated adenomatous polyposis coli (APC) gene
in the plasma of patients with advanced stage colorectal cancers. Decreased expression
of the adenomatous polyposis coli (Apc) gene and/or its homologs was
also observed after exposure to PB and PTU. Eighty-five percent of colorectal cancers
result from chromosomal instability, with acquired mutations
progressively accumulating in the adenomatous polyposis coli (APC) and
p53 tumor suppressor genes, and in the k-ras oncogene. |
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