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adenocarcinoma in situ

   Also found in: Acronyms 0.01 sec.
adenocarcinoma in situ,
a localized growth of abnormal glandular tissue that may become malignant. However, the abnormal cells do not extend beyond the basement membrane. It is most common in the endometrium and in the large intestine.


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The FDA's Vaccines and Related Biological Products Advisory Committee, voted 12-1 that data on the Glaxo-SmithKline Biolog-icals HPV bivalent (types 16 and 18) vaccine, recombinant, supported the efficacy of the vaccine for preventing HPV 16/ 18-re-lated cervical cancer, cervical intraepithelial neoplasia (CIN) 2+, adenocarcinoma in situ (AIS), and CIN1+ in girls and women aged 15-25 years.
Adenocarcinoma in situ Hysterectomy is the recommended treatment.
In some instances (especially when the endocervical tumor is present in surface epithelium and/or glands only) the endocervical neoplasm may actually be a separate primary adenocarcinoma in situ or invasive adenocarcinoma.
 
 
 
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