adeno-associated virus


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De·pen·do·vi·rus

(dē-pen'dō-vī'rŭs),
A genus of small defective single-stranded DNA viruses in the family Parvoviridae that depend on adenoviruses for replication.
[L. dependeo, to be dependent upon, + virus]

Adeno-Associated Virus

A member of the parvovirus family, which is composed of small viruses with a genome of a single-stranded DNA. AAVs insert genomic material at a specific site on human chromosome 19 with nearly 100% certainty, and are used to construct vectors that introduce genes into cultured cells. There is virtually no downside to AAV vectors, given the small amount of DNA they can carry and because AAV is non-pathogenic (most people are AAV carriers). In contrast to adenoviruses, AAV usually does not trigger an immune response to cells infected with it, and thus can deliver genes to sites of interest, including the brain in the context of gene therapy for diseases of muscle and eye, tissues where AAV seems to be most useful.

adeno-associated virus

a replication-defective, single-stranded DNA virus classifed in the genus Dependovirus of the family Parvoviridae. They depend on help provided by coinfection with adenoviruses for their replication. Not known to cause disease.
References in periodicals archive ?
When investigators transferred the adeno-associated virus with mini-dystrophin to the biceps of six patients with Duchenne muscular dystrophy, it provoked an unexpected immune response.
The company is focused on building its adeno-associated virus (AAV) therapeutic capabilities and advancing multiple gene therapy programs in rare diseases, and is advancing a wholly-owned hemophilia B program towards clinical development.
It is a possibility that the serotype of adeno-associated virus used in the study may not be the most efficient vehicle.
Avalanche's Ocular BioFactory(TM) platform technology is a proprietary adeno-associated virus (AAV)-based gene therapy discovery and development technology optimized for ophthalmology that utilizes a directed evolution approach to generate novel drug candidates.
Adeno-associated virus type 2 (AAV2) is a virus that regularly infects humans but causes no disease.
Targeted Genetics Corporation (Seattle, WA) announced the issuance of an additional patent related to its adeno-associated virus vector construct.
SEATTLE -- An adeno-associated virus has safely delivered a transmembrane conductance regulator gene into the cells of 70 cystic fibrosis patients, Barrie J.
No treatment for LCA is currently available, but subretinal delivery of recombinant adeno-associated virus (rAAV) vectors expressing RPE65 has demonstrated substantial restoration of visual function in mouse and dog models of RPE65-associated blindness, and initial clinical trials in small numbers of patients have been encouraging.
Marrazzo's presentation will highlight the company's progress in developing potentially curative, one-time gene therapies for the treatment of inherited blindness and hemophilia, and provide an overview of Spark's expertise and capabilities in the clinical development of adeno-associated virus (AAV) vectors.
Objective: Inherited retinal degenerations are a primary clinical focus of adeno-associated virus (V) mediated gene therapy.
SERCA2a is delivered via an adeno-associated virus vector-an inactive virus that acts as a medication transporter-into cardiac cells.
The patent, United States 6,537,540, is titled "Methods and Compositions for Lowering the Level of Tumor Necrosis Factor in TNF-Associated Disorders" and includes the use of adeno-associated virus (AAV) vectors -- carriers responsible for the transfer of a therapeutic gene (protein) of interest into mammals -- to deliver a TNF antagonist that reduces the levels of TNF in several related diseases.