adeno-associated virus


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De·pen·do·vi·rus

(dē-pen'dō-vī'rŭs),
A genus of small defective single-stranded DNA viruses in the family Parvoviridae that depend on adenoviruses for replication.
[L. dependeo, to be dependent upon, + virus]

Adeno-Associated Virus

A member of the parvovirus family, which is composed of small viruses with a genome of a single-stranded DNA. AAVs insert genomic material at a specific site on human chromosome 19 with nearly 100% certainty, and are used to construct vectors that introduce genes into cultured cells. There is virtually no downside to AAV vectors, given the small amount of DNA they can carry and because AAV is non-pathogenic (most people are AAV carriers). In contrast to adenoviruses, AAV usually does not trigger an immune response to cells infected with it, and thus can deliver genes to sites of interest, including the brain in the context of gene therapy for diseases of muscle and eye, tissues where AAV seems to be most useful.

adeno-associated virus

a replication-defective, single-stranded DNA virus classifed in the genus Dependovirus of the family Parvoviridae. They depend on help provided by coinfection with adenoviruses for their replication. Not known to cause disease.
References in periodicals archive ?
Duchenne muscular dystrophy is caused by mutations in the very large dystrophin gene, which is too large to transfer when incorporated into the tiny adeno-associated virus.
Separation of two types of adeno-associated virus particles containing complementary polynucleotide chains.
AGTC is focused on the research and development of novel therapeutics for patients with unmet medical needs utilizing AGTC's proprietary, non-pathogenic adeno-associated virus (AAV) delivery system.
Freeline's technology utilises engineered adeno-associated virus vectors for the treatment of bleeding and other debilitating disorders.
The collaboration will enable Oxford Genetics and MeiraGTx to develop novel adeno-associated virus (AAV) vectors, as well as packaging and producer cell lines.
It also brings an advanced recombinant Adeno-Associated Virus vector design and production technology, and a fully functional Phase I/II gene therapy manufacturing facility that Bamboo acquired from the University of North Carolina earlier this year.
The team also leveraged preexisting technology in designing a delivery vehicle -- an engineered adeno-associated virus, a small, relatively innocuous virus that causes no disease.
Wilson, MD, PhD, demonstrated that a single dose of an adeno-associated virus (V) expressing a broadly neutralizing flu antibody into the nasal passages of mice and ferrets gives them complete protection and substantial reductions in flu replication when exposed to lethal strains of H5N1 and H1N1 flu virus.
Key words: Newcastle disease virus, immunoglobulin A, avian adeno-associated virus.
Targeted Genetics Corporation (Seattle, WA) announced the issuance of another patent related to the company's leading adeno-associated virus (AAV) technology platform.
The therapy uses a genetically altered adeno-associated virus (AAV) to deliver genes into the body.