addressins

addressins

Components in cell membranes that mediate adhesion to particular molecules on the surfaces of other cells. They function to effect cell-to-cell interactions and to help in the distribution of cells within an organism.

addressins

tissue-specific molecules in vascular endothelium which are involved in directing extravasation of recirculating lymphocytes.
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For example, the specialized endothelial cells that line the high endothelial venules in lymph nodes and Peyer's patches constitutively express so-called addressins (mucosal vascular addressin cell adhesion molecule 1 [MAdCAM-1]), which support the homing of naive lymphocytes, whereas endothelial cells elsewhere permit no leukocyte binding unless they are exposed to inflammatory mediators.
The activation, recruitment and retention of immune cells in the genital mucosa involve obligatory and intimate interactions between the pathogen and accessory molecules such as addressins, chemokine receptors, integrins, adhesion molecules on the host cells.