addressin


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ad·dres·sin

(ad-res'in),
A molecule on the surface of a cell that serves as a homing device to direct another molecule to a specific location.
[address, fr. O.Fr. adresser, to direct, fr. L.L. addirectiare, fr. L. ad, to, + directus, straight, direct, + -in]

addressin

A protein encoded by MADCAM1 on chromosome 19p13.3, which is a member of the immunoglobulin family and similar to ICAM1 and VCAM1. It is an endothelial cell-adhesion molecule which interacts preferentially with the leukocytes beta7 integrin LPAM-1, L-selectin and VLA-4 on myeloid cells, directing leukocytes into mucosal and inflamed tissues.

ad·dres·sin

(ă-dres'in)
A molecule on the surface of a cell that serves as a homing device to direct another molecule to a specific location.
[address, fr. O.Fr. adresser, to direct, fr. L.L. addirectiare, fr. L. ad, to, + directus, straight, direct, + -in]
References in periodicals archive ?
Vedolizumab, developed for the treatment of UC and CD, is a humanized monoclonal antibody that is designed to specifically antagonize the alpha4beta7 integrin, inhibiting the binding of alpha4beta7 to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and fibronectin, but not vascular cell adhesion molecule 1 (VCAM-1).
vedolizumab) Entyvio, an integrin receptor antagonist, is a humanized monoclonal antibody that specifically binds to the alpha4beta7 integrin and blocks the interaction of alpha4beta7 integrin with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and inhibits the migration of memory T-lymphocytes across the endothelium into inflamed gastrointestinal parenchymal tissue.
Focused or planning and enacting I in classroom, assisting students, and addressin administrative issues with PBL implementation.
Organisation Mission : For GEF SGP, the community-based approach is the cornerstone for addressin
For example, the specialized endothelial cells that line the high endothelial venules in lymph nodes and Peyer's patches constitutively express so-called addressins (mucosal vascular addressin cell adhesion molecule 1 [MAdCAM-1]), which support the homing of naive lymphocytes, whereas endothelial cells elsewhere permit no leukocyte binding unless they are exposed to inflammatory mediators.
IgA responses are augmented by antigen delivery to the mucosal addressin cellular adhesion molecule1.
2] Human genes: BRCA1, breast cancer 1, early onset; BRCA2, breast cancer 2, early onset; MGST3, microsomal glutathione S-transferase 3; GBP1, guanylate binding protein 1, interferon-inducible, 67kDa; MTAP, methylthioadenosine phosphorylase; GGH, gamma-glutamyl hydrolase (conjugase, folylpolygamma-glutamyl hydrolase); MADCAM1, mucosal vascular addressin cell adhesion molecule 1; POSTN, periostin, osteoblast specific factor; PMS1, PMS1 postmeiotic segregation increased 1 (S.
11) CD44 binds to a wide range of molecules in its extracellular environment including hyaluronan, osteopontin, collagen, fibronectin, fibrinogen, laminin, chondroitin sulfate, mucosal vascular addressin, serglycin/gp600, major histocompatibility complex class II invariant chain, (12) and E-selectin.
And shockingly, it is notthe first time that tragedyhas struck the family at the addressIn the early 1990sMrs Byrne's husband, also named Martin, died after falling down the stairs at the house in Kyrwicks Lane, just off the Stratford Road in the city.
n Readers' letters, whether by post, fax or email, must be accompanied by a full postal addressin order to be considered for publication
New multimedia services that will use the emerging standard Session Initiation Protocol (SIP), along with the voice features of Succession CSE MX, will allow flexible network deployment while addressin g the challenges of mobility, enabling enterprise users to have access to the same powerful applications regardless of location.
She urged continued common scripture study in order to reflect on past and present Jewish-Christian relations, more adequately addressin g the church's origin within Judaism, more appreciation for the Jewish tradition on the part of Christian teachers, better understanding of each faith's concept of revelation, and learning about other scriptures and traditions in order to view Jewish-Christian dialogue in a wider interreligious context.