adaptive trial


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adaptive trial

A form of research in which data analyzed as the trial progresses are used to reshape or refocus its design.
See also: trial
References in periodicals archive ?
Despite their well-perceived advantages, the adaptive trials are complex to design, require more upfront planning, and are often met with statistical, procedural, logistic and regulatory challenges.
ISR's new adaptive trial report is based on a survey of 102 pharmaceutical decision-makers who have experience with adaptive trials.
Kristin Pothier, EY's Life Sciences Commercial Advisory Services Leader, says: "At a time when it is critical for companies of all sizes to conduct R&D as efficiently as possible, adaptive trials, precision medicine and precompetitive collaborations have the potential to unlock additional value that is trapped in the pipelines of biotech companies.
This agreement follows a collaboration that PPD entered into with Berry Consultants last year in Bayesian design and analysis, areas of adaptive trial design that have brought significant changes to how clinical research is conducted.
Today we are proud to showcase our latest advances including our newest statistical applications for patient enrichment in ADDPLAN([R]) PE and our integrated platform, AptivAdvantage[TM], designed to meet the stringent requirements of adaptive trial execution.
SAN DIEGO, May 30, 2013 /PRNewswire/ -- SynteractHCR, a leading full-service global contract research organization (CRO), has completed validation and training on East, Cytel's adaptive trial software, enhancing its consulting services on adaptive trials to its clients, especially for those smaller or emerging companies that may not have the resources to run adaptive trial simulations in-house.
Aptiv Solutions is uniquely positioned to assist clients in addressing both of these changes and I look forward to further building our market presence as the leading provider of adaptive trial design, execution and clinical trial services.
Aptiv Solutions, a biopharmaceutical and medical device development services company, and leader in adaptive clinical trial design, simulation and execution, announced today the latest release in its proprietary suite of adaptive trial software: ADDPLAN([R]) 6.
This adaptive trial design allows data evaluation to determine if the probability of reaching a statistically significant endpoint has been achieved.
Adaptive trial designs allow the use of information gained from an ongoing trial to refine the study, thereby improving clinical trial success rates, as well as identifying unsuccessful trials earlier.
In this collaboration, Aptiv Solutions has licensed the use of FACTS(TM), the adaptive trial design software developed by Tessella and Berry Consultants for early phase clinical studies.

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