The same study also demonstrated greater improvements in quality of life and patient satisfaction after 12 weeks of topical fixed-dose adapalene
is at the top of the tolerability list, said Dr.
Chapter 6 is about the effects of retinoids on the sebaceous gland, essentially on the treatment of acne with tretinoin, tazarotene, and adapalene
topically, and isotretinoin orally, with detailed consideration of irritation and other side-effects, and chapter 8 deals with retinoid treatment of disorders of cornification such as ichthyosis.
5% of patients, respectively, at 3 months, were no longer reported by patients 12 months into adapalene
was as effective as tretinoin for the treatment of mild to moderate acne, while producing significantly less irritation, Dr.
Standard topical treatments for acne in black patients include benzoyl peroxide, topical antibiotics, and topical retinoids such as tretinoin, adapalene
, and tazarotene.
gel worked just as quickly and effectively as Retin A Micro in clearing acne, but it caused less dryness, stinging, burning, erythema, and scaling in a 12-week trial that included 168 patients.
gel resulted in significantly lower lesion counts than placebo (Arch.
The three topical retinoids currently approved for use in the United States--tretinoin, adapalene
, and tazarotene--all decrease formation of microcomedos and subsequent acne lesions.
Although many treatment options are available, even the most commonly prescribed topical therapeutics, like Adapalene
for acne and Metronidazole for rosacea, result in adverse side effects like skin irritations, driving the need for improved treatments with higher efficacy levels and better safety profiles.
Data that will be presented on March 23 at the American Academy of Dermatology's 55th Annual Meeting indicate that adapalene
There was a quick, statistically significant difference in the decrease in open and closed comedones in favor of tazarotene over adapalene
cream," he reported.