ACER2

(redirected from acylsphingosine deacylase 3-like)

ACER2

A gene on chromosome 9p22.1 that encodes an enzyme which hydrolyses ceramide into sphingosine and free fatty acid. It inhibits protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and LAMP1, by increasing sphingosine levels; inhibits cell adhesion by reducing ITGB1 on the cell surface; and may have a role in cell proliferation and apoptosis, which reflects a ying-yang relationship between sphingosine and sphingosine-1-phosphate.