The nine target genes were acyl-CoA synthetase long-chain family member 6 (ACSL6), apolipoprotein A-I (APOA1), PLTP, GK, CPT2, aquaporin 7 (AQP7), acyl-Coenzyme A oxidase 1 palmitoyl (ACOX1), ACOX2, and FABP4.
The first step of the [beta]-oxidation cycle is catalyzed by acyl-coenzyme A dehydrogenases and acyl-CoA oxidases in the two respective systems.
3,4) Another reason for this decline may be improvement in the diagnosis of metabolic diseases, such as medium-chain acyl-coenzyme A dehydrogenase deficiency, that cause illnesses similar to Reye's syndrome.
Table 1 Metabolic disorders that have presentations similar to Reye's syndrome Disorders of ureagencsis Partial ornithine transcarbamoylasc deficiency Partial carbamoylphosphatc deficicncy Partial arginosuccinic acid synthase deficiency Disorders of mitochondrial fatty acid oxidation and ketogenesis Medium-chain acyl-coenzyme A dehydrogenase deficiency Light-chain acyl-coenzyme A dehydrogenase deficiency Carnitine transport defect Organic acidurias Glutaricaciduria, type 1 Carbohydrate metabolism Respiratory-chain disorders
Specific examples of current projects include acyl-coenzyme A
diacylglycerol acyltransferase (DGAT), 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), desaturases, and a family of histone deacetylases (HDACs).
These include isoforms of the facilitated glucose transporters (GLUT), the glutamate transporters, cationic amino acid transporters, fatty acid transporters, fatty acid binding proteins, aldolases, acyl-Coenzyme A
oxidases, long-chain acyl-CoA synthetases, acylglycerol-3-phosphate O-acyltransferases, phosphatidic acid phosphatases, and suppressor of cytokine signaling genes.