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acyl-CoA dehydrogenase |
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acyl-CoA dehydrogenase /ac·yl-CoA de·hy·dro·gen·ase/ (de-hi´dro-jen-ās) any of several enzymes that catalyze the oxidation of acyl coenzyme A thioesters as a step in the degradation of fatty acids. Individual enzymes are specific for certain ranges of acyl chain lengths: long-chain a.-CoA d. (LCAD), medium-chain a.-CoA d. (MCAD), and short-chain a.-CoA d. (SCAD). How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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An
international team of doctors recently reported successes in using
ketones to treat three children with the rare genetic disease known as
multiple acyl-CoA dehydrogenase deficiency, or MADD. [21] The
activity levels of acyl-CoA dehydrogenase and HAD ([beta]oxidation
enzymes) and CS, NAD-isocitrate dehydrogenase, and 2-oxoglutarate
dehydrogenase (citric acid cycle enzymes) were decreased in 24-month-old
untrained male Wistar rats' soleus muscles ("red
oxidative") as compared with the soleus muscles of 6-month-old
untrained rats. As part of the January observance of Birth Defects Prevention
Month, the March of Dimes is announcing it has widened its core list of
recommended newborn screening tests for all states to include the
metabolic disorder called medium chain acyl-CoA dehydrogenase (MCAD)
deficiency -- affecting about 1 in every 15,000 infants born in the
U. |
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