acyl-CoA dehydrogenase

acyl-CoA dehydrogenase

/ac·yl-CoA de·hy·dro·gen·ase/ (de-hi´dro-jen-ās) any of several enzymes that catalyze the oxidation of acyl coenzyme A thioesters as a step in the degradation of fatty acids. Individual enzymes are specific for certain ranges of acyl chain lengths: long-chain a.-CoA d. (LCAD), medium-chain a.-CoA d. (MCAD), and short-chain a.-CoA d. (SCAD).
References in periodicals archive ?
Higher expression of acyl-CoA dehydrogenase genes in adipose tissues of obese compared to lean pig breeds.
Conditions currently screened for in Wales are congenital hypothyroidism, cystic fibrosis, medium chain acyl-CoA dehydrogenase deficiency (MCADD), phenylketonuria and sickle cell disorders.
Primers flanking exonic and promoter regions of the genes galactosylceramidase (GALC), [4] medium and very long chain acyl-CoA dehydrogenases [acyl-CoA dehydrogenase, C-4 to C-12 straight chain (ACADM) and acyl-CoA dehydrogenase, very long chain ACADVL)], galactose-1-phosphate uridyl transferase (GALT), and phenylalanine hydroxylase (PAH) were designed in the NYS NBS program using the Primer3[TM] free software available at http://frodo.
We were able to save about 15 babies with medium-chain acyl-CoA dehydrogenase or MCAD deficiency, a condition that prevents the body from converting certain fats in food to energy," Dr al-Rifai said, adding: "The early detection has allowed for early treatment.
Primer sequences for acetyl-CoA acyltransferase (ACAA2), long-chain acyl-CoA dehydrogenase (ACADL), acyl-CoA synthetase (ACSL1), very long chain acyl-CoA dehydrogenase (ACADVL), carnitine palmitoyltransferase 1B (CPT1B), enoyl-CoA hydratase (ECH1), hydroxyacyl-CoA dehydrogenase (HADHA), pyruvate dehydrogenase kinase (PDK4), PGC-1[alpha], PGC-1[beta], PPAR[alpha], glutamate dehydrogenase, and 18S ribosomal RNA are available in Supplemental Material, Table S1 (http://dx.
MCAD stands for medium-chain acyl-CoA dehydrogenase.
The newborn blood spot (also known as 'heel prick') screens for phenylketonuria, congenital hypothyroidism, sickle cell disease, cystic fibrosis and medium-chain acyl-CoA dehydrogenase deficiency (MCADD).
MCADD (medium chain acyl-coa dehydrogenase deficiency) (1 in 10,000 risk) where the baby cannot break down fats to make energy for the body.
In another inherited disorder, medium-chain acyl-CoA dehydrogenase deficiency (MCAD), the enzyme that is responsible for breaking down fats into energy, is missing or does not work correctly.
An international team of doctors recently reported successes in using ketones to treat three children with the rare genetic disease known as multiple acyl-CoA dehydrogenase deficiency, or MADD.
Another is MCAD (medium chain acyl-CoA dehydrogenase deficiency), a disorder that affects the ability to process fat and may be responsible for up to 10 percent of deaths attributed to sudden infant death syndrome.

Full browser ?