acyl-CoA


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ac·yl-CoA

(as'il),
Condensation product of a carboxylic acid and coenzyme A; metabolic intermediate of importance, notably in the oxidation and synthesis of fats.
Synonym(s): acyl-coenzyme A

ac·yl-CoA

(as'il-kō-ā)
Condensation product of a carboxylic acid and coenzyme A; metabolic intermediate of importance, notably in the oxidation and synthesis of fat.
References in periodicals archive ?
Some of the defective pathways in multiple acyl-CoA dehydrogenase deficiency.
Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet.
Infants suspected to have very-long chain acyl-CoA dehydrogenase deficiency from newborn screening.
Very long chain acyl-CoA dehydrogenase deficiency: identification of a new inborn error of mitochondrial fatty acid oxidation in fibroblasts.
Lack of carnitine leads to toxic accumulation of long-chain fatty acids in cytoplasm and acyl-coA in mitochondrion.
In fact, it is found in every cell of the body, where it is an intracellular transporter of a metabolite called acyl-CoA.
We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of L-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA uptake into mitochondria for beta]-oxidation.
MACD (medium-chain acyl-CoA dehydrogenase deficiency)
We were able to save about 15 babies with medium-chain acyl-CoA dehydrogenase or MCAD deficiency, a condition that prevents the body from converting certain fats in food to energy," Dr al-Rifai said, adding: "The early detection has allowed for early treatment.
Primer sequences for acetyl-CoA acyltransferase (ACAA2), long-chain acyl-CoA dehydrogenase (ACADL), acyl-CoA synthetase (ACSL1), very long chain acyl-CoA dehydrogenase (ACADVL), carnitine palmitoyltransferase 1B (CPT1B), enoyl-CoA hydratase (ECH1), hydroxyacyl-CoA dehydrogenase (HADHA), pyruvate dehydrogenase kinase (PDK4), PGC-1[alpha], PGC-1[beta], PPAR[alpha], glutamate dehydrogenase, and 18S ribosomal RNA are available in Supplemental Material, Table S1 (http://dx.

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