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acyl CoA |
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| Transcription regulation of peroxisomal fatty acyl CoA oxidase
and enoy-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by
peroxisome proliferators. Whatever the precise mechanism by which PPs induce rodent liver
cancer, rodent liver peroxisome proliferation, induction of the
peroxisomal gene acyl CoA oxidase (ACO) (23), hypertrophy (24), and
carcinogenicity (25) are all mediated through activation of the
peroxisome proliferator-activated receptor (PPAR[alpha]). cite the finding of an inactive PP response
element upstream of the acyl CoA oxidase gene in a sample human
population (15) as additional evidence for why humans may be less
responsive than rodents to PPs. |
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