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acyl CoA

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acyl CoA /ac·yl CoA/ (a´sil ko-a´) acyl coenzyme A.
acyl CoA
abbr.
acyl coenzyme A

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Transcription regulation of peroxisomal fatty acyl CoA oxidase and enoy-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.
Whatever the precise mechanism by which PPs induce rodent liver cancer, rodent liver peroxisome proliferation, induction of the peroxisomal gene acyl CoA oxidase (ACO) (23), hypertrophy (24), and carcinogenicity (25) are all mediated through activation of the peroxisome proliferator-activated receptor (PPAR[alpha]).
cite the finding of an inactive PP response element upstream of the acyl CoA oxidase gene in a sample human population (15) as additional evidence for why humans may be less responsive than rodents to PPs.
 
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