acute zonal occult outer retinopathy


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acute zonal occult outer retinopathy (AZOOR),

syndrome characterized by acute loss of one or more zones of outer retinal function, photopsia, minimal funduscopic changes, and electroretinography abnormalities affecting one or both eyes.

Acute Zonal Occult Outer Retinopathy

An often bilateral condition affecting young white women, typically presenting with central photopsia, progressive scotomata and blurring of vision. The fundal examination is strikingly unremarkable despite marked electrophysiologically detectable retinal dysfunction. AZOOR stabilises over months with the development of retinal pigment epithelial atrophy and intraretinal pigment migration corresponding to the zones of field loss.
Aetiology Viral or autoimmune aetiology.
AZOOR shares much in common with the other “white dot” syndromes, including acute idiopathic blind spot enlargement syndrome, acute macular neuroretinitis, multifocal choroiditis with panuveitis, multiple evanescent white dots syndrome, multifocal inner choroiditis, pseudo-presumed ocular histoplasmosis syndrome, and punctate inner choroiditis, all of which affect young females and may be accompanied by unexplained visual field loss and similar electrophysiologic defects.
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