Initial Final (n) (n) Test Proposed Animals Tests Animals tests required required (a) (a) Acute toxicity
, 87 5,220 111 6,660 fish Acute toxicity
, 26 440 16 185 mammal Repeated dose 23 1,172 15 755 toxicity Developmental 29 33,640 11 12,200 toxicity Reproductive 11 12,760 8 9,280 toxicity Combined 129 74,820 166 96,280 protocols CAD (in vivo) 29 1,450 22 1,100 Total 334 129,502 349 126,460 (a) Number of animals based on standard or median number of animals per test as shown in Table 2.
For sensory control of the organisms, acute toxicity
tests were performed periodically using a reference substance with 96h of duration.
OECD (Organization for Economic Cooperation and Development) (1984) 'Earthworm, acute toxicity
after excessive ingestion of colchicine.
Screenhouse experiments were undertaken to evaluate the acute toxicity
of Silwet L-77 (99.
The increases in marijuana potency are of concern since they increase the likelihood of acute toxicity
, including mental impairment," notes Nora Volkow, director of NIDA.
to life forms is generally restricted to the free hydrogen cyanide in the solution.
Its promising memory-restoring Alzheimer's drug Caprospinol expects to enter a Phase I clinical trial after acute toxicity
study and its High Stress Cortisol drug to counteract Cushing's disease expects to enter Phase II clinical trials.
Pharmaceuticals: A European assessment of drug research practices published in Regulatory Toxicology and Pharmacology has found that acute toxicity
tests on animals are unnecessary.
Twelve of 196 (6%) total dry weather samples exhibited acute toxicity
during this study.
Rabbits treated orally with whole dried dandelion plants at 3-6 g/kg body weight showed no visible signs of acute toxicity
Yet fewer than half of the thousands of chemicals currently used in commerce have been tested for acute toxicity
, and, although new chemicals undergo more thorough testing, access to the data may be restricted because companies fear exposing proprietary information.