acute promyelocytic leukaemia


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acute promyelocytic leukaemia

A subtype of leukaemia that comprises 10% of AML, which has a poor prognosis in children. It is characterised by a retinoic acid receptor alpha translocation (RARA) (t(15;17) and PML-RARA gene rearrangement) and is uniquely responsive to all trans retinoic acid (ATRA), which drives the leukaemic cells to maturation.

Clinical findings
Fatigue, weakness and dyspnea due to anaemia; bruisability and bleeding due to low platelets; fever, infections due to leukopaenia, DIC, and splenomegaly.
 
Management
Induction with ATRA, followed by conventional chemotherapy, commonly an anthracycline plus cytarabine.

a·cute pro·my·e·lo·cyt·ic leu·ke·mi·a

(ă-kyūt' prō'mī-ĕ-lō-sit'ik lū-kē'mē-ă)
The disorder presenting as a severe bleeding disorder, with infiltration of the bone marrow by abnormal promyelocytes and myelocytes, low plasma fibrinogen, and defective coagulation.
Synonym(s): acute promyelocytic leukaemia.

a·cute pro·my·e·lo·cyt·ic leu·ke·mi·a

(ă-kyūt' prō'mī-ĕ-lō-sit'ik lū-kē'mē-ă)
Leukemia as a severe bleeding disorder, with infiltration of the bone marrow by abnormal promyelocytes and myelocytes, a low plasma fibrinogen level, and defective coagulation.
Synonym(s): acute promyelocytic leukaemia.
References in periodicals archive ?
Acute promyelocytic leukaemia, APL, is probably one of the best-understood malignancies and the only one where highly efficient oncogene-targeted therapies (retinoic acid and arsenic) actually cure the disease.
It was set up by Melissa Ginns and Ian Mustard following the loss of Ian's 16-year-old daughter Abbie from acute promyelocytic leukaemia in 2013.
Funded by the charity Leukaemia & Lymphoma Research, the scientists have spent five years studying data from 231 people diagnosed with acute promyelocytic leukaemia (APL).
Funded by the charity Leukaemia & Lymphoma Research, for five years the scientists have studied data from 231 people diagnosed with acute promyelocytic leukaemia (APL).
Doctors diagnosed him as having acute promyelocytic leukaemia, which is a rare form of the disease and stops blood clotting.
FLT3 internal tandem duplication (ITD) mutation was predominant in acute promyelocytic leukaemia patients with bcr3 isoform.
Acute promyelocytic leukaemia (APL) was recognised as a distinct subtype of acute myeloid leukaemia (AML) in 1957 and affects 4-11% of children with AML.
Simon was diagnosed with Acute Promyelocytic Leukaemia in July, 2004.
Food and Drug Administration to treat patients with relapsed or refractory Acute Promyelocytic Leukaemia (APL), a rare, life-threatening form of cancer of the blood.
Early indications of efficacy are for CNS cancer, myelodysplastic syndrome, acute myelogenous leukaemia, acute promyelocytic leukaemia, and colon cancer.
Abbie's Hideaway was established in 2013 to allow families with terminally ill children to spend quality time together on holiday and was set up by Melissa Ginns and Ian Mustard after the loss of Ian's 16-year-old daughter Abbie from acute promyelocytic leukaemia in November 2012.

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