acute posterior multifocal placoid pigment epitheliopathy


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Acute Posterior Multifocal Placoid Pigment Epitheliopathy

A disease of the retinal macula seen in otherwise healthy young patients, who develop bilateral acute onset visual disturbance—e.g., scotomas, blurred vision, red eye or floaters, scintillating scotomas, and hemianopic blur; initial acuity varies widely by site of retinal involvement with one-third of eyes having less than 20/100 when first seen.
Aetiology Idiopathic; influenza-like illness.
Systemic defects in APMPPE Erythema nodosum, TB, sarcoidosis, nephritis, thyroiditis, potentially fatal cerebral vasculitis, CSF defects.
Fundoscopy Multiple, yellow-white, flat (placoid) lesions in macula at the level of the retinal pigment epithelium (RPE); lesions are well-circumscribed and discrete; the overlying retina usually appears normal and subretinal fluid is rare; vitritis and iritis are uncommon and mild.
Fluorescein angiography Acute lesions are hypofluorescent, then stain with increasing hyperfluorescence; inactive lesions may fluoresce as window defects due to depigmentation of the RPE.
Prognosis Good; the norm is a rapid regression of the fundus lesions and a delayed return of visual acuity to near normal levels.

a·cute pos·te·rior mul·ti·fo·cal pla·coid pig·ment ep·i·the·li·op·a·thy

(ă-kyūt' pos-tēr'ē-ŏr mŭl-tē-fō'kăl plak'oyd pig'mĕnt ep'i-thē-lē-op'ă-thē)
An acute, inflammatory, self-limited disease manifested by decreased vision and multifocal, cream-colored placoid lesions of the retinal pigment epithelium; resolves with restoration of vision.

acute posterior multifocal placoid pigment epitheliopathy

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APMPPE

An acute, transient inflammation of the retina, retinal pigment epithelium, and choroid that impacts visual acuity. It is thought to be caused by a hypersensitivity reaction and usually improves without systemic effects or the need for treatment.
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