acute phase protein


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Related to acute phase protein: negative acute phase reactant, Acute phase reactants, acute phase response, C reactive protein

acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Serum amyloid A (SAA) belongs to the group of acute phase proteins (APP) that are produced in cases of infection, tissue injury, trauma, surgery, neoplastic growth, or immunologic disorders.
1) Acute phase proteins are already used as valuable health indicators in humans and domestic animals (cattle, horses, dogs, cats, fowl, turkeys, pigs, and rabbits) and in wildlife, (1-22) The assessment of this protein can provide valuable diagnostic information for the detection, prognosis, and monitoring of disease.
Acute phase proteins, and SAA in particular, are used as an indicator of health status in many species.
Identification of acute phase proteins and assays applicable in non-domesticated mammals.
Acute phase proteins in dogs and cats: current knowledge and future perspectives.
Measurement of serum acute phase proteins to monitor postoperative recovery in anoestrous bitches after ovariohysterectomy.
Acute phase proteins in cattle: Discrimination between acute and chronic inflammation.
Study on acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, and ceruloplasmin) changes and their diagnostic values in bovine tropical theileriosis.
Let's take a look at some of these acute phase proteins.
Proteins whose plasma concentrations change by 25% during inflammatory states are defined as acute phase proteins.
Since the ESR is an indirect measurement of acute phase proteins, non-inflammatory conditions (such as change in the morphology and concentration of erythrocytes) or a change in activity or concentrations of other plasma proteins (as in multiple myeloma) can elevate the ESR.
Acute phase proteins such as ESR and CRP are nonspecific and in many cases, nonsensitive.

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