acute phase protein


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acute phase protein

plasma proteins associated with inflammation including C-reactive protein (CRP), mannose-binding protein, serum amyloid P component, α1-antitrypsin, fibrinogen, ceruloplasmin, and complement components C9 and factor B, the concentrations of which increase in response to interleukins 1, 6, and 11.

acute phase protein

Any of the plasma proteins whose concentration increases or decreases by at least 25% during inflammation. Acute-phase proteins include C-reactive protein, several complement and coagulation factors, transport proteins, amyloid, and antiprotease enzymes. They help mediate both positive and negative effects of acute and chronic inflammation, including chemotaxis, phagocytosis, protection against oxygen radicals, and tissue repair. In clinical medicine the erythrocyte sedimentation rate or serum C-reactive protein level sometimes is used as a marker of increased amounts of acute-phase proteins. Synonym: acute phase reactant See: inflammation
See also: protein
References in periodicals archive ?
Serial measurements of acute phase proteins in patients with acute coronary syndrome.
Current research on acute phase proteins in veterinary diagnosis: an overview.
Nevertheless, elevation of both acute phase proteins was a poor prognostic sign and the results emphasize the importance of monitoring levels of these proteins on admission, during management and before discharge.
The intense exercise produces an inflammatory reaction (acute phase reaction) with a change of acute phase proteins by both glycogen depletion, as e microlesions musculature, reported in sled dogs (WAKSHLAG et al.
Serum amyloid A (SAA) belongs to the group of acute phase proteins (APP) that are produced in cases of infection, tissue injury, trauma, surgery, neoplastic growth, or immunologic disorders.
18 The acute phase proteins regulate immune responses, function as mediators and inhibitors of inflamma-tion, act as transport proteins for products generated during the inflammatory process (the haem-binding protein hemopexin, and haptoglobin), function as opsonins, activate complement, bind cellular rem-nants like nuclear fractions9,18, scavenge free haemo-globin and radicals, modulate the host's immune response, prevent apoptosis and / or play an active role in tissue repair and tissue remodeling.
Lack of correlation between clinical disease activity and erythrocyte sedimentation rate, acute phase proteins or protease inhibitors in ankylosing spondylitis.
Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection.
Periodontitis is a bacterial disease of the gums with an inflammatory component that is associated with an increase in plasma CRP, an acute phase protein and marker of systemic inflammation.
Periodontitis is a bacterial disease of the gums with an inflammatory component that is associated with an increase in plasma C-reactive protein (CRP), an acute phase protein and marker of systemic inflammation.

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