acute lymphocytic leukemia
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Related to acute lymphocytic leukemia: acute myeloid leukemia
Acute leukemia is characterized by fatigue, headache, sore throat, and dyspnea, followed by symptoms of acute tonsillitis, stomatitis, bleeding from the mucous membranes of the mouth, alimentary canal, and rectum, and pain in the bones and joints. There eventually is enlargement of the lymph nodes, liver, and spleen. Common to all leukemias are the tendency to bleed and the resultant anemia and increased susceptibility to infection. The diagnosis of leukemia requires confirmation of leukemic cells in the bone marrow by bone marrow biopsy and aspiration. Abnormalities may also be seen in peripheral blood smears.
Because of the malignant nature of leukemia and the fear and anxiety created by the knowledge that one has a form of cancer, patients and their families and significant others will need help in coping with anxiety, mental depression, and realistic fears about dying and death. The financial burden of the illness and disruption of the life of the individual and the family also impose a special burden on them. Referral to appropriate persons and agencies that can help meet their needs is an essential part of the holistic care of the patient with leukemia.
acute lymphocytic leukemia (ALL)
acute lymphocytic leukemiaAcute lymphoblastic leukemia, ALL A malignant lymphoproliferative process that commonly affects children and young adults affecting ± 1800/yr–US; ± 650/yr–UK Etiology ALL has a hereditary component; it is 20 X ↑ Pts with Down syndrome; it is linked to benzene exposure, RT in ankylosing spondylitis; it is unrelated to exposure to magnetic fields Clinical Abrupt onset, often ± 3 month Hx of fatigue, fever, hemorrhage from multiple sites, lymphadenopathy, hepatomegaly, splenomegaly Prognosis 9% long-term disease-free survival–1962-66; 71%–1984-88–St Jude's Children's Hospital; 90-95% achieve remission; improved cure rate is attributed to prophylaxis for meningeal leukemia and more intense systemic chemotherapy
lym·pho·cyt·ic leu·ke·mi·a(lim'fō-sit'ik lū-kē'mē-ă)
Synonym(s): lymphatic leukemia.
acute lymphocytic leukemiaAbbreviation: ALL
Any of a wide range of acquired or congenital chromosomal abnormalities can cause ALL, including lesions that result in the release of excess growth factors from cells and those that cause the loss of cancer-suppressing genes.
Fatigue, lethargy, bleeding, bone and joint pain, and a predisposition to fever and infection are characteristic of ALL and other leukemias.
The disease is suggested by the presence of abnormalities on the complete blood count or peripheral blood smear and is confirmed by immunophenotyping.
In childhood, ALL induction chemotherapy often begins with steroids, vinca alkaloids, and asparaginase. This is followed, after bone marrow recovery, by consolidation chemotherapy with multidrug regimens, including high-dose methotrexate. Maintenance therapies, which may last 2 years or longer, include methotrexate, mercaptopurines, and other cytotoxic agents. Prophylaxis against central nervous system disease is accomplished by intrathecal drug administration. In referral hospitals, allogeneic stem cell transplantation is sometimes used for refractory disease. About 90% of treated children achieve remission. The 5-year survival of children with ALL is about 85%. Adult ALL is much less responsive to therapy; only about a third of adult patients are cured. In both childhood and adult ALL, allopurinol and hydration precede induction chemotherapy to prevent hyperuricemia caused by tumor lysis.
Late complications of therapy are not uncommon.
Patient discussion about acute lymphocytic leukemia
Q. What is the best treatment for Acute Lymphocytic Leukemia? What is the best treatment for Acute Lymphocytic Leukemia? Can you please give me the hospital names and the location where the treatment could be done?