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acute lymphocytic leukemia |
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acute lymphocytic leukemia Acute lymphoblastic leukemia, ALL A malignant lymphoproliferative process that commonly affects children and young adults affecting ± 1800/yr–US; ± 650/yr–UK Etiology ALL has a hereditary component; it is 20 X ↑ Pts with Down syndrome; it is linked to benzene exposure, RT in ankylosing spondylitis; it is unrelated to exposure to magnetic fields Clinical Abrupt onset, often ± 3 month Hx of fatigue, fever, hemorrhage from multiple sites, lymphadenopathy, hepatomegaly, splenomegaly Prognosis 9% long-term disease-free survival–1962-66; 71%–1984-88–St Jude's Children's Hospital; 90-95% achieve remission; improved cure rate is attributed to prophylaxis for meningeal leukemia and more intense systemic chemotherapy How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| People with acute lymphocytic leukemia are more likely than healthy
people to have the common version of a gene that plays a role in
regulating folic acid metabolism in the body, a new study shows. The study is a multi-center, open label, dose escalation trial and
will investigate the safety, tolerability, pharmacokinetics and
preliminary efficacy of INNO-406 in adult patients with
imatinib-resistant or intolerant Philadelphia positive (Ph+) leukemias
or relapsed/refractory Ph+ acute lymphocytic leukemia (ALL). Of the 20 with lymphoid blast crisis or acute lymphocytic leukemia,
70 percent had a response, including four with complete responses, the
researchers said. |
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acute lymphocytic leukemia
