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acute hepatitis |
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acute hepatitis
Clinical medicine Liver inflammation of abrupt onset, which may be due to a viral infection–eg HAV or toxins Clinical Low-grade fever, anorexia, N&V, fatigue, malaise, headache, photophobia, pharyngitis, cough;
later, dark urine, light stool, jaundice, hepatomegaly, ± splenomegaly, ± lymphadenopathy Diagnosis Liver biopsy; ↑ transaminases–ALT, AST, ↑ virus-specific IgG or IgM Pathology Diffuse lymphocytic and plasmacytic
inflammation, patchy–piecemeal necrosis, and liver cell degeneration in the form of either lytic–ballooning or coagulative–acidophilic degeneration; AH may be accompanied by a collapse of the central reticulin fibers surrounding
the hepatocytes; activated Kupffer cells may be filled with phagocytic debris. Cf Chronic hepatitis. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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