acute febrile neutrophilic dermatosis

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a·cute fe·brile neu·tro·phil·ic der·ma·to·sis

a rare dermatosis, predominant in women, of rapid onset and characterized by plaquelike lesions, usually multiple, on the face, neck, and upper extremities, accompanied by conjunctivitis, mucosal lesions, fever, malaise, arthralgia, and peripheral blood neutrophilia in many cases; biopsy reveals polymorphonuclear infiltrate of the dermis; rapid remission occurs with systemic steroid therapy.
Synonym(s): Sweet disease

acute febrile neutrophilic dermatosis

An uncommon self-limited (5–12 weeks) condition characterised by single or multiple erythematous papules and plaques ± accompanied by pustules; it is more common in females; in males, it is associated with cancer including lymphoma, leukaemia, solid tumours and myeloproliferative disorders; it is also associated with ulcerative colitis, monoclonal gammopathies, rheumatoid arthritis, erythema nodosum, Sjögren syndrome, lupus erythematosus, vaccinations and various infections
Management Systemic steroids


Robert Douglas, 20th century English dermatologist.
Sweet disease - Synonym(s): acute febrile neutrophilic dermatosis; Sweet syndrome
Sweet syndrome - Synonym(s): Sweet disease
References in periodicals archive ?
Colchicine in the treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome).
Zamanian A, Ameri A: Acute febrile neutrophilic dermatosis (Sweet's syndrome): a study of 15 cases in Iran.
Gottlieb CC, Mishra A, Belliveau D, Green P, Heathcote JG: Ocular involvement in acute febrile neutrophilic dermatosis (Sweet syndrome): new cases and review of the literature.

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