acute HIV syndrome

acute HIV syndrome

Acute HIV infection, primary symptomatic HIV infection A transient, flu-like early response to HIV-1, that occurs 1-6 wks after exposure to HIV-1 in 50-70% of those with 1º HIV infection; AHS presents as an acute infectious mononucleosis-like complex and is accompanied by viremia and an immune response to HIV within 1 wk to 3 months Clinical Fever, severe fatigue, sore throat, lymphadenopathy, anorexia, N&V, and a maculopapular rash, less commonly, diarrhea, lightning-like pain, major weight loss, abdominal cramping, palmoplantar desquamation, myalgia, arthralgia, headache, photophobia, lymphadenopathy, pruritic maculopapular or urticarial rash, lymphocytic meningoencephalitis and peripheral neuropathy, all Sx remit, and reappear as AIDS after a latency of up to several yrs Lab Mild leukopenia, occasionally inversion of the CD4:CD8 ratio, antibodies to HIV products–gp120, gp160, p24 and p41 first appear ≥ months after infection. See AIDS, CD4:CD8 ratio, HIV-1.