activin


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ac·tiv·in

(ak'ti-vin),
Placental hormone that reaches maximum levels in maternal serum during labor; helps to regulate production of gonadotropin-releasing hormones, human chorionic gonadotropin, and steroids by the placenta.
[active + -in]

activin

/ac·ti·vin/ (ak´tĭ-vin) a nonsteroidal regulator synthesized in the pituitary glands and gonads that stimulates the secretion of follicle-stimulating hormone.

activin

(ăk′tə-vĭn, ăk-tĭv′ĭn)
n.
A polypeptide growth factor that is synthesized in the pituitary gland and the gonads and stimulates the secretion of follicle-stimulating hormone.

Activin

Either of two dimeric proteins belonging to the TGF-beta superfamily (as do inhibin and bone morphogenic protein) which act primarily through SMADs, a class of signal transducers, which are involved in DNA-binding and signal transduction. Activins are involved in all stages of the cell cycle: proliferation, differentiation, metabolism, homeostasis, and death (apoptosis), as well as immune response and tissue repair—activins A and B are highly expressed during wound repair and healing, and have yin-yang relationship with inhibin. Activins are involved in differentiation of erythroid precursors and erythroleukemia cell lines, neuronal survival, stimulation of insulin and anterior pituitary hormone secretion, regulation of the menstrual cycle, increasing FSH production and granulosa cell differentiation by binding to follistatin, an FSH release inhibitor.

ac·tiv·in

(ak'ti-vin)
Placental hormone that reaches maximum levels in maternal serum during labor.

activin

a gonadal peptide hormone isolated from follicular fluid; has an unidentified role in stimulating FSH secretion.
References in periodicals archive ?
By exposing the cells to a signaling molecule at two different timepoints, the team could trigger first Wnt, then Activin, and end up with specialized cells.
Activin A and B are also members of the TGF-[beta] superfamily, and have a variety of actions in both embryonic and adult tissues, including tissue fate determination in vertebrate embryos, regulation of follicle-stimulating hormone biosynthesis in pituitary gonadotrophs, and regulation of gametogenesis in ovaries and testes (Welt et al.
In an existing study (5), it has been indicated that hiPSCs could be efficiently differentiated into the endoderm cells through EBs formation in the differentiation media, including Activin A, ITS and B27 supplements using hMSCs feeder.
Activins are heterodimers (AYAAYB, activin AB) or two homodimers (AYAAYA, activin-A; AYBAYB, activin B) of the AY subunits of inhibin.
Three of these Fec genes identified in sheep are bone morphogenetic protein receptor type IB (BMPRIB) or Activin Like Kinase 6, known as FecB located on chromosome 6;[3,4,5] growth differentiation factor (GDF9), known as FecG located on chromosome 5 [6,7] and bone morphogenetic protein 15 (BMP15), known as FecX located on the X chromosome the full lenght.
Activin inhibits pituitary prolactin expression and cell growth through Smads Pit-1 and menin.
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2.
Washington, Nov 15 ( ANI ): Biologists have documented a direct association between insulin and life span, suggesting that blocking the activity of a protein complex activin can lengthen a fruit fly's life span by as much as 20 percent, which is about 10 days.
The disulfide-linked mature dimer of BMPs will associate with membrane receptors that have been identified as type I receptors--BMPRIA (or activin receptor-like kinase 3--ALK3) and BMPRIB (or ALK6), and type II receptor--BMPRII (Yamashita et al.
Oxidant damage triggers a molecule called Activin A to go to work, the researchers reported last year in Breast Cancer Research.
In return, these stellate cells produce large quantities of Nodal and activin.