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active site

   Also found in: Dictionary/thesaurus, Legal, Financial, Encyclopedia, Wikipedia, Hutchinson 0.01 sec.
active site
n.
The part of an enzyme molecule at which catalysis of the substrate occurs.

active site,
the place on the surface of an enzyme where its catalytic action occurs.

active
not passive.

active principle
the drugs or chemicals in a pharmaceutical preparation that exert an effect pharmacologically; as distinct from the inert fillers, wetting agents and other excipients also often included.
active site
that region of a protein, usually an enzyme, that binds to another molecule such as the substrate of the enzyme.
active transport
the movement of ions or molecules assisted by a carrier protein across the cell membranes and epithelial layers, usually against a concentration gradient, resulting directly from the expenditure of metabolic energy. For example, under normal circumstances more potassium ions are present within the cell and more sodium ions extracellularly. The process of maintaining these normal differences in electrolytic composition between the intracellular fluids is active transport. The process differs from simple diffusion or osmosis in that it requires the expenditure of metabolic energy.


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Oseltamivir resistance caused by a single amino acid substitution from histidine (H) to tyrosine (Y) at position 274 of the neuraminidase active site has been reported in persons infected both experimentally and naturally with influenza A virus subtype H5N1 (1,2).
The glyphosate-based herbicide disrupts aromatase activity and mRNA levels and interacts with the active site of the purified enzyme, but the effects of glyphosate are facilitated by the Roundup formulation in microsomes or in cell culture.
Long misperceived in the West as a Conceptualist, Ilya Kabakov is, rather, an imagist and a fantasist who constructs situations in which the work's most active site is the viewer's imagination.
 
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