active placebo


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pla·ce·bo

(plă-sē'bō),
1. An inert substance given as a medicine for its suggestive effect.
2. An inert compound identical in appearance to material being tested in experimental research, which may or may not be known to the physician or patient, administered to distinguish between drug action and suggestive effect of the material under study.
Synonym(s): active placebo
[L. I will please, future of placeo]
A placebo with side effects similar to those of a therapeutic agent—administered in the context of a therapeutic trial, which would otherwise allow a patient to identify whether he/she is receiving drug or placebo—e.g., dry mouth with chlorpromazine

active placebo

Statistics A placebo with side effects similar to those of a therapeutic agent which would otherwise allow a Pt to identify whether he is receiving drug or placebo–eg, dry mouth is associated with chlorpromazine. See Placebo.

pla·ce·bo

(plă-sē'bō)
Inert substance given as a medicine for its suggestive effect.
Synonym(s): active placebo.
[L. I will please, future of placeo]
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References in periodicals archive ?
Further randomized, placebo-controlled, double-blind studies are clearly needed to assess the efficacy and effectiveness of different antidepressant medications, at different dosages, compared with one another and with placebo (if possible, an active placebo with side effects similar to those of the active drug).
Active placebo was used in an attempt to replicate the hypnotic quality of morphine, although two-thirds of placebo patients correctly guessed this particular treatment assignment.
Subsequent chapters address placebo design, active placebos, and other design features for identifying, minimizing, and characterizing placebo response; psychological processes that can bias responses; the case for changing the term "placebo effect"; effects in complementary and alternative medicine; meta-analyses and experimental studies; the role of desire, expectation, and reduced negative emotions in placebo anti-hyperalgesia in irritable bowel syndrome; placebo, pain, and surgery; placebo interventions for pain; how communication between clinicians and patients may impact pain perception; nocebos in daily clinical practice; recommendations for pain management; and ethical issues.