active metabolite

Active Metabolite

A drug metabolite with therapeutic activity similar to that of its parent compound, which must be considered in evaluating therapeutic pharmacokinetics.

active metabolite

Therapeutics A drug metabolite with therapeutic activity similar to the parent compound, which must be considered in therapeutic pharmacokinetics
References in periodicals archive ?
As Modufolin is the key active metabolite of leucovorin and levoleucovorin, it does not need to be activated in the body.
Twelve hours after the first dose was administered, mean (SD) concentrations of tramadol and its only active metabolite M1 (Odesmethyltramadol) were 53 [+ or -] 57 ng/mL and 6 [+ or -] 6 ng/mL, respectively.
A later forensic report also showed NA's urine sample contained both cocaine and benzyolecgonine, an active metabolite in cocaine.
Teriflunomide is the active metabolite of leflunomide, a synthetic, low-molecular-weight drug that was approved by the FDA in 1998 for the treatment of rheumatoid arthritis.
In the journal BMC Medicine, researchers from Texas Tech University Health Sciences report the discovery of a mechanism for diindolylmethane (DIM), an active metabolite of indole-3-carbinol found in cruciferous vegetables, to induce programmed cell death (apoptosis) in cultured ovarian cancer cells.
The benefits of tamoxifen as part of a sequential approach could be enhanced by ensuring that we do not jeopardize the metabolism of tamoxifen to its active metabolite, endoxifen, by the coadministration of CYP inhibitors.
Teriflunomide is the active metabolite of leflunomide, a synthetic, low-molecular-weight drug that was approved by the Food and Drug Administration in 1998 for the treatment of rheumatoid arthritis.
in CYP2C19 on the pharmacokinetics of the active metabolite of Effient
Following oral administration of oseltamivir, after de-esterification of the compound, primarily the active metabolite oseltamivir carboxylate is produced.
Tamoxifen has a major protective effect against cancer recurrence and requires a particular liver enzyme to convert it to its active metabolite.
It is the active metabolite of nitroglycerin, which has been used to treat coronary artery disease for more than 100 years.
Oseltamivir carboxylate (OC), Tamiflu's active metabolite, is known to withstand activated sludge treatment at sewage treatment plants (STPs), but less is known about how much OC may make its way into waterways that receive STP effluent.