activated (redirected from activated clotting time (ACT))

activated

a state of being more than usually active. In biological systems this is usually brought about by chemical or electrical means. Commonly said of pharmaceutical and chemical products.

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activated clotting time (ACT)

a simplified version of the activated partial thromboplastin time which measures the intrinsic clotting activity of the whole blood. See also activated coagulation time, clotting time.

activated partial thromboplastin time (APTT)

a test of intrinsic clotting activity of whole blood. Partial prothrombin, usually rabbit or human brain prothrombins, is added to plasma activated with kaolin or ellagic acid. The time required for the test is short and the results are dependable.

activated sludge

a method of dealing with sewage and abattoir effluent. Consists of an aeration tank in which biologically active, previously sedimented sludge is mixed with incoming effluent and agitated in the presence of an ample supply of air.

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drotrecogin alfa (activated) Warning - High-alert drug!

Xigris

Pharmacologic class: Activated protein C (recombinant)

Therapeutic class: Antisepsis drug

Pregnancy risk category C

Action

Antisepsis action unknown. May produce indirect profibrinolytic activity by hindering plasminogen activator inhibitor-1 and limiting generation of activated thrombin-activatable fibrinolysis inhibitor. Produces anti-inflammatory effect by inhibiting human tumor necrosis factor production and suppressing thrombin-induced inflammatory responses.

Availability

Powder for injection (lyophilized): 5 mg, 20 mg

⊘Indications and dosages

➣ Severe sepsis

Adults: 24 mcg/kg/hour I.V. for a total duration of 96 hours

Contraindications

• Hypersensitivity to drug or its components
• Intracranial neoplasm or lesion or evidence of cerebral herniation
• Intracranial or intraspinal surgery within past 2 months
• Hemorrhagic stroke within past 3 months
• Severe head trauma or trauma with increased risk of bleeding
• Active bleeding or high risk of bleeding
• Patients undergoing bone marrow therapy
• Current use of epidural catheter

Precautions

Use cautiously in:
• intracranial arteriovenous malformation, chronic severe hepatic disease, recent GI bleeding
• concurrent use of heparin, thrombolytics, oral anticoagulants, or aspirin
• pregnant patients
• children (safety and efficacy not established).

Administration

• Mix with normal saline solution, lactated Ringer's solution, or dextrose 5% in water.
• Prepare immediately before use. Hang infusion bag within 3 hours of reconstitution; complete infusion within 12 hours after preparation.
• Administer only through infusion pump.
• Don't infuse with any other drug.
• Give entire regimen over 96 hours.
☞ Discontinue drug 2 hours before invasive procedures.
• Be aware that once hemostasis occurs, drug therapy may resume immediately after uncomplicated invasive procedures or 12 hours after major invasive procedures (such as surgery).

Route	Onset	Peak	Duration
I.V.	Rapid	Unknown	Unknown

Adverse reactions

CNS: intracranial hemorrhage

GI: intra-abdominal, retroperitoneal, or other GI tract bleeding

GU: bleeding

Hematologic: bleeding

Skin: bruising

Other: skin and soft-tissue bleeding, intrathoracic bleeding

Interactions

Drug-drug. Anticoagulants, aspirin, glycoprotein IIb/IIIa inhibitors, indomethacin, phenylbutazone, thrombolytics: increased risk of bleeding

Drug-diagnostic tests. Activated partial thromboplastin time (APTT), prothrombin time (PT): prolonged

Hematocrit: decreased

Patient monitoring

☞ Know that no antidote exists. Monitor closely for signs and symptoms of hemorrhage. Stop infusion if clinically significant bleeding occurs.
• Monitor PT and CBC (especially platelet count).
• Realize that drug may variably prolong APTT and thus doesn't reliably indicate coagulopathy.

Patient teaching

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

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Patient discussion about activated clotting time (ACT).

Q. My son who is 4yrs old is so hyper-active. How do I find out if my son has ADHD or ADD? My son who is 4yrs old is so hyper-active that he climbs on everything and jumps off everything to. I cannot prevent that. I have also punished him. He cries for a split moment and then he just goes back to doing the same thing. I've tried every type of punishment that I could think of. I'm afraid of him. What can I do? How do I find out if my son has ADHD or ADD?

A. I agree complete physical and psycho analysis to rule out any underlying cause. But young children often act out characters; you could ask him why he's doing this and give plenty of proper oportunities to do so. Example when he climbs on and jumps off the furniture ask him what he is doing. He may be pretending to be something or someone. If so ask him where "so and So" does their jumping and ask or remind him what the funiture is for. explain how to properly use it have him demonstrate. Example: " What is a chair for or how do we use a chair? (sitting) "Where" (on the seat, child may touch the seat and answer here) "show me how" (child sits on seat of chair). Praise the positive behavior smiling and then suggest that he can play "so an So" somewhere else at another time: for instance if possible take him out to the playground or in a safe area lie a firm suitcase or other boxlike item on its side, cover with a soft quilt and supervise his c

Q. How does drinking a lot of water before an activity helps to avoid dehydration? Question Description It just makes me go to the bathroom more…

A. you need to drink water before,during and after any sports or exercises,because you sweat which causes dehydration.

Q. why do i have problems with my right hip?i am 38 and i've been working out alot since jan of 92.why the hip? i am very physically active.i am 38.not overweight at all.i am 5-9 and a half and i weigh 180-185 lbs.i have problems with my right hip.hard to exactly explain how it does it's thing on me.i got back into practicing karate kicks in 98 after a 7 year hiatus.i ride my bicycle alot and i do dips,pullups,and moderate level weight lifting.i think maybe its the bicycle sprints that i like to incorporate in my bicycling.what do you's think...?

A. i do not get tingling or burning.i never suffered trauma to the hip.
i do not have pain during the night.only if i stood up all of a sudden right on the bed after laying there for hours would it possibly act up.
during my regular waken hours,if i sit for a prolonged period of time and then go to get up too soon or too quick,i will get the pain.it just always feels like i badly pulled something,or it temporarily went out of place.then i cease further movement for around 10 seconds and sort of let it settle back into place and i do this sort of hip rotational thing to help loosen the area and then,i'm usually good for awhile after that.i havent been to a doctor or orthopedic surgeon because i know how many doctors can be and they might try to convince me that i absolutely have to get surgery or i'll be crippled in a few years.i know how docs like to use scare tactics alot of times and do surgeries that the patient didnt really have to get to begin with.i'm leary about docs in general.