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actinomycin D |
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actinomycin D. See dactinomycin. actinomycin D Cosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma,
Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrhea How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| (7) The chemotherapeutic element of the
IRS IV protocol is significantly different from its predecessors in that
the newer agents etoposide, ifosfamide, and melphalan have been added to
the standard treatment with vincristine, actinomycin D, and
cyclophosphamide. [25] According to Tefft et al,[26] the use of drugs such
as actinomycin D, Adriamycin, and cyclophosphamide to enhance the
effects of radiation has resulted in damaged bone. Thus even with prior exposure of the
cells to the toxic chemotherapeutic drug actinomycin D, the cells did
not die. |
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