Actinomycin D | definition of actinomycin D by Medical dictionary
Also found in: Dictionary
An antineoplastic antibiotic produced by several species of Streptomyces
(for example, S. parvulus
See also: actinomycins
Actinomycin D A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea
actinomycin D Cosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma, Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrhea
actinomycin D Dactinomycin, an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .
actinomycin D a substance that inhibits the transcription of RNA from DNA. When isolated from soil bacteria and used pharmaceutically it acts as an ANTIBIOTIC.