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actinomycin D

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actinomycin D.
actinomycin D
Cosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma, Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrhea


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A THERMODYNAMIC AND KINETIC STUDY OF ACTINOMYCIN D BINDING TO ATYPICAL-T(G)nT-SEQUENCES IN DOUBLE STRANDED DNA.
Also included is a more historical paper describing sixty rears of research in characterizing the sequence-selective DNA-binding agent, actinomycin D.
Lucanthone has structural and biochemical similarities to Actinomycin D but has no hematological or GI toxicity at clinically tolerated doses.
 
 
 
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