actinomycin D


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dac·ti·no·my·cin

(dak'ti-nō-mī'sin),
An antineoplastic antibiotic produced by several species of Streptomyces (for example, S. parvulus).
See also: actinomycins.
Synonym(s): actinomycin D

actinomycin D

actinomycin D

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea

actinomycin D

Cosmegen®, dactinomycin Oncology A relatively toxic antibiotic produced by Streptomyces spp, used as a chemotherapeutic Mechanism Inhibits DNA transcription by RNA polymerase Indications Rhabdomyosarcoma, Wilms' tumor Adverse effects Anorexia, N&V, myelosuppression with pancytopenia, diarrhea

actinomycin D

Dactinomycin, an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .

actinomycin D

a substance that inhibits the transcription of RNA from DNA. When isolated from soil bacteria and used pharmaceutically it acts as an ANTIBIOTIC.