acrosin


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ac·ro·sin

(ak'rō-sin), [MIM*102480]
A serine proteinase in sperm (spermatozoa) similar in specificity to trypsin.

Acrosin

A sperm serine protease encoded by ACR, which is formed from proacrosin by cleavage at lysine and arginine, and inhibited by antitrypsins. Acrosin lyses the ovum’s zona pellucida, facilitating sperm penetration through the innermost glycoprotein layers of the ovum.

ac·ro·sin

(ak'rō-sin)
A serine proteinase in sperms similar in specificity to trypsin.

acrosin

one of the enzymes in the acrosome on the head of a mammalian spermatozoon. Involved in the penetration of the zona pellucida of the ovum by the spermatozoon.
References in periodicals archive ?
In general, when spermatozoa reach the oocyte, they initiate the acrosome reaction and release an enzyme called acrosin, which degrades the oocyte ZP to allow spermatozoa to penetrate into the oocyte cytosol, where the fertilization is finally completed.
Acrosin, the most widely used acrosomal enzyme associated with the acrosome of all mammalian spermatozoa was assessed by the method of Bhattacharya and Zeneveld (1978), Bhattacharya et al.
The mechanism of action seems to be by disrupting the plasma membrane integrity as they caused drastic inhibition on sperm membrane specific enzymes like acrosin and 5' nuleotidase.
Release of acrosin and acrosin inhibitor from human spermatozoa.
Spartiumjunceum Reduced rate of fertility and Broom acrosin enzyme activity.
Kennedy WP, Vander Ven HH, Straus JW, Bhattacharya AK, Waller DP, Zaneveld LJD, Polakoski KL (1983) Gossypol inhibition of acrosin and proacrosin and oocyte penetration by human spermatozoa.
Acrosin antibodies present in the sera of infertile women inhibit spermzona pellucida binding through protease activity (8).
Demonstration of proacrosin and quantitation of acrosin in ejaculated human spermatazoa.