Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to acridine: acridine dyes


a crystalline hydrocarbon, C14h10, from coal tar, used in making dyes.


A dye, dye intermediate, and antiseptic precursor (for example, 9-aminoacridine, acriflavine, proflavine hemisulfate) derived from coal tar and irritating to skin and mucous membranes; a potent mutagen.
Synonym(s): dibenzopyridine


/ac·ri·dine/ (ak´rĭ-dēn) an alkaloid from anthracene used in the synthesis of dyes and drugs.


a dibenzopyridine compound used in the synthesis of dyes and drugs. Its derivatives include fluorescent yellow dyes and the antiseptic agents acriflavine hydrochloride, acriflavine base, and proflavine.


A dye molecule capable of causing a FRAME-SHIFT MUTATION in DNA by interposing between adjacent base pairs. Acridine orange stains nucleic acid so that under ultraviolet light DNA appears green and RNA appears orange.

acridine (orange) (ak´ridēn),

n a dibenzopyridine compound used in the synthesis of dyes and drugs. In dentistry, has been used to research dental deposits.


a dibenzopyridine compound used in the synthesis of dyes and drugs. Derivatives of acridine are successful as antibacterial agents, finding their principal use as local antiseptics. They were popular at one time as antibabesial and trypanocidal agents. See also acriflavine, proflavine.

acridine orange stain
binds nonspecifically to nucleic acids, proteins, polysaccharides and glycosaminoglycans. Together with fluorescent microscopy, it is reportedly more sensitive than conventional staining methods for demonstrating Mycoplasma haemofelis in blood smears.
References in periodicals archive ?
5) for 7 min and 4) staining with working solution of acridine orange and later visualization under fluorescent microscope with suitable filter.
We thank Christian Schmeer for his technical support concerning microscopy of the acridine orange slide and Clara Lettl and Cecilia Hizo-Teufel for excellent technical assistance.
2]: Magnesium chloride MTT: 3-[4,5-Dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide DCFH-DA: 2',7'Dichlorofluorescein diacetate AO: Acridine orange PI: Propidium iodide cDNA: Complementary DNA RT: Reverse transcription SOD: Superoxide dismutase JNK: c-Jun N-terminal kinase p53: Tumor protein p53.
Acridine Orange (AO) staining was used in live zebrafish embryos to visualize the apoptotic cells and assess the level of neurotoxicity in zebrafish embryos.
Lysosomal permeabilization was visualized using Acridine Orange and lysosomal protease cathepsin b expression was determined using Western blot.
Clearing allowed imaging with excellent cellular and nuclear resolution of SYTOX Green or acridine orange-stained specimens more than 500 [micro]m deep into formalin-fixed human prostate, liver, breast, and kidney samples (Figures 1, a through d; 2, a through d).
Currently, different types of cyotchemical tests such as aniline blue, toluiden blue, chromomycine A3 and acridine orang stainings, sperm chromatin dispersion (SCD), sperm chromatin structure assay (SCSA), comet assay and TUNEL assay are available for sperm DNA and chromatin evaluation and each of them has its own advantages and disadvantages (2).
Blood was smeared on an acridine orange-coated slide (Molecular Probes, USA), covered with a cover slip, and analyzed according to Hayashi et al.
Genotoxicity of maleic hydrazide, acridine and DEHP in Allium cepa root cells performed by two different laboratories.