Both chemicals (such as aniline dyes, pesticides, and fava beans) and medications (including dapsone, nitrous oxide, and quinine-based antimalaria drugs) can cause acquired methemoglobinemia (3).
Although this is also the case for other M hemoglobins, it is not an issue in acquired methemoglobinemia or methemo globin reductase deficiency (since methemoglobin A is produced in these instances).
I would like to add to this well written article that we have also reported acquired methemoglobinemia
cases with administration of cytanest in puerperal women with G6PD deficiency and infants in whom erythrocyte cytochrome 65 reductase was assoyed (1-4), which is the main enzyme for methemoglobin reductase in erythrocytes as mentioned by the authors.
When patients become cyanotic: acquired methemoglobinemia
Drugs that cause acquired methemoglobinemia
are prevalent in both the hospital and the outpatient setting.
and hemolytic anemia following excessive pyridium (phenazopyridine hydrochloride) ingestion.
Dapsone is a common cause of acquired methemoglobinemia
Objective: This study aimed to determine the etiologic factors of acquired methemoglobinemia
in infants younger than three months in our region.
Treatment of high-risk, refractory acquired methemoglobinemia
with automated red cell blood cell exchange.
3) reviewed 138 acquired methemoglobinemia
cases, of which 42% were caused by dapsone, followed by benzocaine (4%) and primaquine (4%).
We describe a patient with acquired methemoglobinemia
from dapsone therapy who required anesthetic care for shoulder arthroscopy.
Ascorbic acid is not indicated in the treatment of acquired methemoglobinemia
because the rate at which it reduces methemoglobin is lower than that of the intrinsic enzymatic pathways (24, 35).