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acneiform |
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Dermatologic toxicities, related to Vectibix blockade of EGF
binding and subsequent inhibition of EGF receptor-mediated signaling
pathways, included but were not limited to dermatitis acneiform,
pruritus, erythema, rash, skin exfoliation, paronychia, dry skin, and
skin fissures. With the exception of acneiform rash and infusion reactions, the
incidence of grade 3 or greater toxicity, including mucositis, which
often precludes combining chemotherapies with radiation, did not differ
significantly between the treatment arms.
-- The current dose of ABX-EGF has been set at the level that results in 100% of patients achieving an acneiform skin rash that suggests full blockade of the EGFr. |
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