On histopathology, ductal cancer can resemble high-grade prostatic intraepithelial neoplasia (HGPIN), intraductal prostatic carcinoma, the hyperplastic variant of prostate cancer, cribriform Gleason Pattern 4 acinar
adenocarcinoma, and metastases (including from the colon and bladder).
Pancreatic Ductal Bicarbonate Secretion: Challenge of the Acinar
Invivo stimulation of rat pancreatic acinar
cells by infusion of secretin.
A model of calcium waves in pancreatic and parotid acinar
In 1920, however, Banting read a paper by the American pathologist Moses Barron, who reported a rare case of a pancreatic stone (lithiasis) that had obstructed the main pancreatic duct of a human cadaver; all acinar
cells of the pancreas disappeared (atrophied), but most islet cells remained, results similar to those produced by ligation of pancreatic ducts, as reported in the literature by others (Bliss, 1982: p.
The measurement of amylase and/or lipase, which are released from acinar
cells, currently forms the cornerstone of routine diagnostic laboratory investigations (6).
The solid areas showed a population of monomorphic cells with moderate amount of eosinophilic cytoplasm, arranged in acinar
, trabecular and glandular patterns suggestive of a carcinoid (Figure 1b,1c).
This channel is the major pathway for regulating water permeability in acinar
cells, a critical property of the plasma membrane which determines the flow rate and ionic composition of secreted saliva (Krane et al.
Initial periductal lymphocyte aggregates extend into, and finally destroy, salivary acinar
parenchyma, which leads to small cystic spaces beginning peripherally in the gland.
Patients with more than one prior negative prostate biopsy, a previous diagnosis of prostate cancer, or evidence of high-grade prostatic intraepithelial neoplasia (HGPIN) or atypical small acinar
proliferation (ASAP) on the pre-entry biopsy were excluded.
In the pancreatic acini, the administration of a-difluoromethylornithine, an irreversible inhibitor of polyamine biosynthesis, blocks tissue regeneration [22, 23] and can cause pancreatitis , while appropriate polyamine synthesis is necessary for growth factors to affect pancreatic acinar
Grading of NAFLD Grading of macrovesicular steatosis: Grade 0: None Grade l: Up to 33% Grade 2: 33-66% Grade 3: >66% Grading of nonalcoholic steatohepatitis: Mild (Grade) Steatosis- up to 66% Balloned hepatocytes-occasional (zone 3) Scattered infra-acinar
neutrophils [+ or -] lymphocytes Portal inflammation - none or mild Moderate Steatosis- any degree (Grade II) Balloned hepatocytes-obvious (zone 3) Infra- acinar
neutrophils ++ lymphocytes + Portal inflammation- mild to moderate Perisinusoidal zone III fibrosis Severe Steatosis- panacinar (Grade III) Balloned hepatocytes- widespread Infra-acinar
neutrophils ++(associated with ballooned hepatocytes) f chronic inflammation Portal inflammation- mild to moderate Source: Ref.