2015 Annual ASCO Meeting: Presented the clinical trial design of the mocetinostat Phase 2 study in patients with previously treated, locally advanced, unresectable or metastatic urothelial carcinoma of the bladder harboring inactivating mutations or deletions of the histone acetyltransferase
genes CREBBP and/or EP300
MCM3AP is an acetyltransferase
that acetylases MCM3, and plays a role in DNA replication (Takei et al.
PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling.
The eis gene encodes an aminoglycoside acetyltransferase
, which has an affinity for KAN.
Paradoxical effects of trichostatin a: Inhibition of nf-y-associated histone acetyltransferase
activity, phosphorylation of hgcn5 and downregulation of cyclin a and b1 mrna.
ELONGATOR (elo), a highly conserved histone acetyltransferase
complex consisting of six subunits, was suggested to play crucial role in regulating plant responses to abscisic acid in Arabidopsis since four of the ELONGATOR mutants exhibit hypersensitivity to this plant hormone (Zhou et al.
Anacardic acid, a histone acetyltransferase
inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549 [v1; ref status: indexed, http://f1000r.
p300 modulates gene expression in an epigenetic manner at high blood alcohol levels.
It is observed in some studies that changes in choline acetyltransferase
activity especially at high altitude are possible.
So far, Mof is the only histone acetyltransferase
found to support the stemness of embryonic stem cells.
aeruginosa either phosphorylate (aminoglycoside phosphoryltransferase (APH)), acetylate (aminoglycoside acetyltransferase
(AAC)), or adenylate (aminoglycoside nucleotidyl-transferase (ANT)) the aminoglycoside.
The exposure to a mixture of one ortho-substituted (non-coplanar) congener and one non-ortho substituted (coplanar) tetrachlorinated PCB congener significantly depressed thyroid hormone level and hippocampal choline acetyltransferase
activity (CHAT), and thereby caused depression of long-term memory in the Morris water maze test (Provost and others 1999).