acetylcholinesterase


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Related to acetylcholinesterase: Acetylcholinesterase inhibitors

acetylcholinesterase

 [as″ĕ-til-ko″lin-es´ter-ās]
an enzyme present in nervous tissue, muscle, and red blood cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid. This enzyme is present throughout the body, but is particularly important at the myoneural junction, where the nerve fibers terminate. Acetylcholine is released when a nerve impulse reaches a myoneural junction. It diffuses across the synaptic cleft and binds to cholinergic receptors on the muscle fibers, causing them to contract. cholinesterase splits acetylcholine into its components, thus stopping stimulation of the muscle fibers. The end products of the metabolism of acetylcholine are taken up by nerve fibers and resynthesized into acetylcholine. The drugs neostigmine, physostigmine, and pyridostigmine inhibit acetylcholinesterase and are used to treat myasthenia gravis, a disease in which the cholinergic receptors are attacked by autoantibodies. The drug extends the effect of acetylcholine on the muscle fiber. Called also true cholinesterase

a·ce·tyl·cho·lin·es·ter·ase

(a-sĕ'til-kō'lin-es'ter-ās), [MIM*100740]
The cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (for example, motor endplates and autonomic ganglia).

acetylcholinesterase

/ac·e·tyl·cho·lin·es·ter·ase/ (AChE) (-ko″lĭ-nes´ter-ās) an enzyme present in the central nervous system, particularly in nervous tissue, muscle, and red cells, that catalyzes the hydrolysis of acetylcholine to choline and acetic acid.

acetylcholinesterase

(ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz′)
n.
An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of acetylcholine.

acetylcholinesterase (AChE)

[-kō′lines′tərās]
an enzyme present at the endings of voluntary nerves and parasympathetic involuntary nerves and autonomic nerve ganglia. It inactivates and prevents the accumulation of the neurotransmitter acetylcholine released during nerve impulse transmission by hydrolyzing the substance to choline and acetate. The action reduces or prevents excessive firing of neurons at neuromuscular junctions.

Acetylcholinesterase

A hydrolase in the membrane of postsynaptic cells which metabolises acetylcholine into choline and acetic acid in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impulse.
Location CNS, red cells, motor endplates

acetylcholinesterase

Neurophysiology A hydrolase that metabolizes acetylcholine to acetyl and choline in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impule; acetylcholinesterase is found in the CNS, RBCs, motor endplates

a·ce·tyl·cho·lin·es·ter·ase

(AChE) (as'ĕ-til-kō'lin-es'tĕr-ās)
One of a family of enzymes capable of catalyzing the hydrolysis of acetylcholine.

acetylcholinesterase

An ENZYME that rapidly inactivates ACETYLCHOLINE by breaking it down to acetic acid and choline. Also known as cholinesterase.

acetylcholinesterase

the enzyme present in the synaptic cleft that destroys acetylcholine (see END PLATE).

Acetylcholinesterase

An enzyme that breaks down acetylcholine.
Mentioned in: Insecticide Poisoning

acetylcholinesterase 

An enzyme that degrades and inactivates acetylcholine. This compound is mainly found in neurons and at neuromuscular junctions. Drugs that inhibit this enzyme (e.g. diisopropyl fluorophosphate, physostigmine, edrophonium, echothiophate, DFP) can be used in the diagnosis and possible treatment of myasthenia gravis as well as certain forms of esotropia and glaucoma. Syn. specific cholinesterase. See anticholinesterase drugs.

a·ce·tyl·cho·lin·es·ter·ase

(as'ĕ-til-kō'lin-es'tĕr-ās) [MIM*100740]
Cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (e.g., motor endplates and autonomic ganglia).

acetylcholinesterase

an enzyme present in nervous tissue, muscle and red cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid; called also true cholinesterase. Abbreviated AChE.

acetylcholinesterase antagonists
organophosphorus compounds and carbamates that act by inactivating acetylcholinesterase; hence poisoning by these compounds has parasympatheticomimetic manifestations.
References in periodicals archive ?
Acetylcholinesterase breaks down acetylcholine into acetate and choline, both of which are difficult to detect.
However, none of the alkaloids detected in the extracts surprisingly correspond with any known acetylcholinesterase inhibitor within this class of compounds.
L-Phenylalanine effect on rat diaphragm acetylcholinesterase and [Na.
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
It also is selective for brain acetylcholinesterase, rather than peripheral acetylcholinesterase, which limits its potential for cholinergic adverse effects.
Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.
Phenserine is a highly selective, reversible acetylcholinesterase inhibitor which may offer an alternative to drugs currently marketed for AD because of its potential for targeting the brain while its rapid disappearance from the blood is expected to reduce the possibility of toxicity.
Like other therapies currently on the market, Reminyl boosts the levels of acetylcholine in the brain by blocking the action of the enzyme acetylcholinesterase.
The drugs, known as acetylcholinesterase inhibitors, block an enzyme involved in controlling the activity of a nerve message chemical.
The other two activities, acetylcholinesterase inhibition and neuro-regeneration seem to be properties of one or another metabolite, but not of Posiphen.
Food and Drug Administration has sanctioned the New Drug Application for Namzaric, a fixed-dose combination of memantine hydrochloride extended-release, a NMDA receptor antagonist, and donepezil hydrochloride, an acetylcholinesterase inhibitor.

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