Accordingly, genotype analysis is indispensable to determine acetylator
status rather than, or as a supplement to phenotyping.
phenotyping during maturation in infants.
5B slow acetylator
phenotypes, compared with the other ethnic subgroups.
2000b) predicted bladder cancer risk for smokers and nonsmokers by acetylator
status, designating never-smoker rapid acetylators
as the reference category.
The wild-type NAT2*4 allele is associated with the rapid acetylator
phenotype and does not have any nucleotide substitutions.
1) reported an excess of N-acetyltransferase 2 (NAT2) slow-acetylation alleles and, consequently, an excess of slow acetylator
genotypes in long-term survivors of this syndrome when they were compared to a group of "friends" (i.
The fast acetylator
phenotype occurs in 10-20% of Asians; 50% of Americans (blacks and whites); and 60-70% of Northern Europeans (39, 40).
The slow and fast acetylator
phenotypes have been associated with increased risk for cancers of the bladder and colon, respectively.
65) recently reported a lethal wasting disease in A/J mice treated with oleylanilide The disease observed in A/J mice, a slow acetylator
strain, paralleled some of the human TOS disease features, whereas their homologous C57BL/6 strain (a fast acetylator
) had no symptoms.
Polymorphism in NAT-2 results in the rapid or slow acetylator
phenotype, which has been implicated in host susceptibility to liver damage by drugs such as isoniazid [71, 72].
h) Distinction was not possible between these 2 haplotypes, but predicted to represent a fast acetylator
9) The authors identify several risk factors for the development of hydralazine-induced lupus including high daily doses, slow acetylator
and HLA-DRw4 phenotypes, therapy greater than 3 months, and female gender.