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acetylator

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acetylator /acet·y·la·tor/ (ah-set´ĭ-la″ter) an organism capable of metabolic acetylation; in humans, acetylator status (fast or slow) is determined by the rate of acetylation of sulfamethazine.
acetylator [ah-set″ĭ-la´ter]
an organism capable of metabolic acetylation. Individuals that differ in their inherited ability to metabolize certain drugs, e.g., isoniazid, are termed fast or slow acetylators.
acetylator
an organism capable of metabolic acetylation. Those animals that differ in their inherited ability to metabolize certain drugs, e.g. isoniazid, are termed fast or slow acetylators.
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Ferguson & Martin Philpott "New Zealand--Fertile Ground for Functional Food Nutrigenomics" (2003) 1 Nutritional Genomics & Functional Foods 1 at 3: 93% of New Zealand Polynesians have a rapid acetylator phenotype, 40% of Europeans have it, people with this phenotype and that eat more well-cooked red meat are at a significantly higher risk of colon cancer.
Nutrigenomics, popular representations and the reification of "race"? by Caulfield, Timothy / Health Law Review
Using those regimens, 64% of rapid and intermediate acetylators and 77% of slow acetylators showed no dose-limiting toxicities or dose delays or holds during treatment.
Genotype-specific dosing may improve tolerance and anticancer activity by McBride, Deborah / ONS Connect
18,19) Between 50% and 60% of Caucasians are 'slow' acetylators, (19-21) while Bi et al (20) reported a 'slow' acetylator prevalence of 10 to 30% among Asians from China and Japan.
An updated review of the literature: risk factors for bladder cancer ... by Delclos, George L. / Southern Medical Journal
 
 
 
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