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acetylation

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acetylation /acet·y·la·tion/ (ah-set″ĭ-la´shun) introduction of an acetyl radical into an organic molecule.
a·cet·y·la·tion (-stl-shn)
n.
A reaction, usually with acetic acid, that introduces an acetyl radical into an organic compound.

acetylation (·sē·t·lā·shn),
n a phase II detoxification pathway occurring in the liver in which acetyl-CoA combines with metabolic products.

acetylation
one of the synthetic biotransformations which operate in the metabolism of drugs in which metabolites are produced that are more readily excreted than the parent drug. Dogs are exceptional amongst the domesticated species in that acetylation does not occur in their tissues. Acetylation is one of the principal metabolic pathways of the sulfonamides.


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Gyongyi Szabo, the doctors he works with, created a winning research project titled "Modulation of histone acetylation by alcohol in inflammation and liver disease.
Lead researcher Professor Matthias Mann, of Novo Nordisk Center for Protein Research at the University of Copenhagen and the Max Planck Institute for Biochemistry, has revealed that the 3,600 acetylation switches were detected in 1,750 different proteins.
S-Nitrosation has been recently found to have similar function as phosphorylation and acetylation because of its association with various pathological cell reactions in signalling networks [6].
 
 
 
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