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acetylation
(redirected from acetylate)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
acetylation /acet·y·la·tion/ (ah-set″ĭ-la´shun) introduction of an acetyl radical into an organic molecule.
a·cet·y·la·tion (-stl-shn)
n.
A reaction, usually with acetic acid, that introduces an acetyl radical into an organic compound.

acetylation (·sē·t·lā·shn),
n a phase II detoxification pathway occurring in the liver in which acetyl-CoA combines with metabolic products.

acetylation
one of the synthetic biotransformations which operate in the metabolism of drugs in which metabolites are produced that are more readily excreted than the parent drug. Dogs are exceptional amongst the domesticated species in that acetylation does not occur in their tissues. Acetylation is one of the principal metabolic pathways of the sulfonamides.


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Vitamin B5, in the form of CoA, can be used to help acetylate proteins, thereby protecting them from chemical breakdown.
Scientists have identified enzymes that acetylate, deacetylate, phosphorylate, dephosphorylate, and methylate histones.
Evidence indicates that ibuprofen, but not rofecoxib (a COX-2 inhibitor), acetaminophen, or diclofenac, interferes with aspirin''s ability to irreversibly acetylate the platelet COX-1 enzyme.
 
 
 
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