Sulforaphane inhibits histone de acetylase
in vivo and suppresses tumourigenesis in Apcmin mice.
Recruitment of the histone acetylase
CBP (CREB-binding protein) to a promoter contributes to increased transcription (Valapour et al.
Administration of BM for two weeks, also reversed the depletion of acetylcholine, the reduction in choline acetylase
activity and the decrease in muscarinic cholinergic receptor binding in the frontal cortex and hippocampus, induced by neurotoxin, colchicines (Bhattacharya et al.
p300/CBP helps stimulate gene expression by two major mechanisms: making direct interactions with core RNA polymerase machinery and using their intrinsic histone acetylase
activity to unravel chromatin structure.
WSG has been shown to inhibit ibotenic acid-induced cognitive deficits in rats by reversing rat brain frontal cortical and hippocampal decreases in acetylcholine, choline acetylase
and cholinergic muscarinic receptors produced by the neurotoxin (Bhattacharya et al.
The role dietary of bioactive compounds on the regulation of histone acetylases
and deacetylases: A review.
MCM3AP is an acetyltransferase that acetylases
MCM3, and plays a role in DNA replication (Takei et al.
This acetylation is catalyzed by histone acetylases
(HATs) that uses acetyl-CoA as substrate and the acetyl group is transferred to the [euro] amino group of certain lysine side chains within histones N-terminal tails and other nuclear receptor proteins thereby regulating chromatin remodeling and gene expression (171).
The smallest unit of chromatin is the nucleosome acetylases
switch genes on by freeing DNA from tightly packed chromatin.
A set of enzymes, such as histone acetylases
, histone deacetylases (HDACs),  histone methyltransferases, and histone demethylases, regulates these reversible processes (5, 6, 9).
(HATs) and histone deacetylases (HDACs).