3] to ADP, orthophosphate and malonyl-CoA, catalysed by the enzyme acetyl-CoA carboxylase
Comment: Biotin is a cofactor for acetyl-CoA carboxylase
, a potentially rate-limiting enzyme in myelin synthesis.
Spangenburg and colleagues further established that the protein produced by the BRCA 1 gene binds with a protein known to play an important role in the metabolism of fat in muscle cells known as Acetyl-CoA carboxylase
Three possible reasons for inhibitory effect of de novo fatty acid synthesis by stearate are as follows: i) Stearate inhibited de novo synthesis of fatty acid by down-regulating the mRNA expression of ACACA and FASN; ii) Long-chain acyl-CoA competed with newly synthesized medium-chain acyl-CoA for the sn-2 and sn-3 positions of the triacylglycerol backbone; iii) long-chain acyl-CoA inhibited de novo synthesis of fatty acid by suppression of acetyl-CoA carboxylase
(Hansen and Knudsen.
2001), as it phosphorylates and regulates enzymes such as acetyl-CoA carboxylase
(ACC) and HMGCoA reductase (Carling et al.
Furthermore, CPP and 5-CQA decreased the nuclear active form of SREBP-1, acetyl-CoA carboxylase
activity, and cellular malonyl-CoA levels.
2] catalyzed by acetyl-CoA carboxylase
, which is the major site of the regulation of fatty acid synthesis.
and fatty acid synthase activity and immunodetectable protein in adipose tissues of ruminants: Effect of temperature and feeding level.
He adduced that the low cholesterol could be as a result of slight reduction in lipogenesis brought about by a concomitant reduction in regulatory activities of acetyl-CoA carboxylase
, an enzyme which mediates in the rate-limiting step of carboxylation of acetyle CoA to malonyl CoA in fatty acids synthesis.
Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase
After 4 days, the animals were anesthetized, and their livers were minced and frozen at -80[degrees]C until measurement of acetyl-CoA carboxylase
(ACC; EC 6.
AMPK is considered as a major regulator of fatty acid synthesis pathway due to its function to phosphorylate and inactivate key enzymes in fatty acid metabolism such as acetyl-CoA carboxylase