acetyl-CoA carboxylase


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a·ce·tyl-CoA car·box·yl·ase

a ligase that catalyzes the reaction of acetyl-CoA, CO2, H2O, and ATP, with covalently bound biotin to form malonyl-CoA, ADP, and Pi (or the reverse decarboxylase); N-carboxybiotin is an intermediate. A crucial enzyme in fatty acid synthesis.

acetyl-CoA carboxylase

/ac·e·tyl-CoA car·box·yl·ase/ (kahr-bok´sĭ-lās) a ligase that catalyzes the rate-limiting step in the synthesis of fatty acids from acetyl groups.
References in periodicals archive ?
Comment: Biotin is a cofactor for acetyl-CoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
Spangenburg and colleagues further established that the protein produced by the BRCA 1 gene binds with a protein known to play an important role in the metabolism of fat in muscle cells known as Acetyl-CoA carboxylase or ACC.
Three possible reasons for inhibitory effect of de novo fatty acid synthesis by stearate are as follows: i) Stearate inhibited de novo synthesis of fatty acid by down-regulating the mRNA expression of ACACA and FASN; ii) Long-chain acyl-CoA competed with newly synthesized medium-chain acyl-CoA for the sn-2 and sn-3 positions of the triacylglycerol backbone; iii) long-chain acyl-CoA inhibited de novo synthesis of fatty acid by suppression of acetyl-CoA carboxylase (Hansen and Knudsen.
2001), as it phosphorylates and regulates enzymes such as acetyl-CoA carboxylase (ACC) and HMGCoA reductase (Carling et al.
Furthermore, CPP and 5-CQA decreased the nuclear active form of SREBP-1, acetyl-CoA carboxylase activity, and cellular malonyl-CoA levels.
2] catalyzed by acetyl-CoA carboxylase, which is the major site of the regulation of fatty acid synthesis.
Acetyl-CoA carboxylase and fatty acid synthase activity and immunodetectable protein in adipose tissues of ruminants: Effect of temperature and feeding level.
He adduced that the low cholesterol could be as a result of slight reduction in lipogenesis brought about by a concomitant reduction in regulatory activities of acetyl-CoA carboxylase, an enzyme which mediates in the rate-limiting step of carboxylation of acetyle CoA to malonyl CoA in fatty acids synthesis.
Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms.
After 4 days, the animals were anesthetized, and their livers were minced and frozen at -80[degrees]C until measurement of acetyl-CoA carboxylase (ACC; EC 6.
AMPK is considered as a major regulator of fatty acid synthesis pathway due to its function to phosphorylate and inactivate key enzymes in fatty acid metabolism such as acetyl-CoA carboxylase (ACC).